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Cattle --- Interferons --- Virus replication --- Gene expression regulation --- Metabolism --- Physiology --- Virology

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Gene expression --- Genetic transcription --- RNA --- Small interfering RNA --- Cancer --- Expression génique --- Transcription génétique --- ARN --- Petits ARN interférents --- Congresses --- Regulation --- Congresses. --- Molecular aspects --- Congrès --- Régulation --- Aspect moléculaire --- Gene Expression Regulation --- Transcription, Genetic --- physiology --- physiology. --- Rna --- Small interfering rna --- Gene expression regulation --- Transcription, genetic --- Physiology. --- Expression génique --- Transcription génétique --- Petits ARN interférents --- Congrès --- Régulation --- Aspect moléculaire

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Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Cancer. --- Cancer cells. --- Carcinogenesis. --- Carcinogenesis - Molecular aspects. --- Carcinogens. --- Gene Expression Regulation, Neoplastic. --- Genomic Instability. --- Neoplasms. --- Carcinogenesis --- Cancer cells --- Cancer --- Gene Expression Regulation, Neoplastic --- Genomic Instability --- Carcinogens --- Genetics --- Neoplasms --- Gene Expression Regulation --- Diseases --- Noxae --- Biology --- Pathologic Processes --- Genetic Phenomena --- Mutation --- Genetic Processes --- Pathological Conditions, Signs and Symptoms --- Genetic Variation --- Phenomena and Processes --- Biological Science Disciplines --- Toxic Actions --- Chemical Actions and Uses --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Pathophysiology --- Genetic aspects --- Molecular aspects. --- Pathophysiology. --- Genetic aspects. --- Cancer genetics --- Molecular carcinogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Cancer genes --- Cells --- Pathology, Cellular --- Pathology, Molecular --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Biomedicine, general. --- Cancer research --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors

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The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.

Histone Deacetylases --- Cell Cycle --- Enzyme Repression --- Neoplasms --- Sirtuins --- Histone deacetylase. --- Cell cycle. --- Enzymes. --- Cancer --- Histone désacétylase --- Cycle cellulaire --- Enzymes --- physiology. --- drug effects. --- antagonists & inhibitors. --- drug therapy. --- Chemotherapy. --- Chimiothérapie --- Cancer -- Chemotherapy. --- Histone deacetylase --- Cell cycle --- Cell Physiological Processes --- Gene Expression Regulation, Enzymologic --- Enzyme Inhibitors --- ADP Ribose Transferases --- Amidohydrolases --- Group III Histone Deacetylases --- Biological Science Disciplines --- Intracellular Signaling Peptides and Proteins --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Molecular Mechanisms of Pharmacological Action --- Pentosyltransferases --- Proteins --- Gene Expression Regulation --- Cell Physiological Phenomena --- Hydrolases --- Disciplines and Occupations --- Glycosyltransferases --- Amino Acids, Peptides, and Proteins --- Pharmacologic Actions --- Phenomena and Processes --- Genetic Processes --- Transferases --- Chemical Actions and Uses --- Enzymes and Coenzymes --- Genetic Phenomena --- Chemicals and Drugs --- Drug Therapy --- Histone Deacetylase Inhibitors --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Chemotherapy --- Biocatalysts --- Ferments --- Soluble ferments --- Mitotic cycle --- Nuclear cycle (Cytology) --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Antineoplastic agents --- Catalysts --- Enzymology --- Biological rhythms --- Amidases --- Treatment --- Oncology. --- Tumors --- Cancer research

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Research is fast paced and advances in RNA interference have recently opened up new opportunities for genetic experiments in human cell lines. However, the possibility to easily modify the genome still remains a powerful tool to investigate the function of coding and regulatory sequences in the vertebrate genome. DT40 has never been a quick and easy road to fame. It would be unfair to blame this on DT40 as it has proven to be a reliable and robust companion with fast doubling time, easy clonability and a relatively stable karyotype. If this model system is going to flourish over the next 15 years, it will be thanks to ingenious and original researchers. They may feel as if they work outside the mainstream, but they can take heart by the fact that only the clever exploitation of diversity and conservation makes biological research both elegant and rewarding. It is with this in mind that the DT40 handbook has been conceived and written. This book provides an up to date overview of the different facets of research, and also intends to help newcomers get started and avoid looming pitfalls. The collection of protocols which have been kindly provided by a number of laboratories will be particularly useful in this regard.

Vertebrates --- Genetic regulation --- Cytogenetics --- Methodology --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Vertebrata --- Chordata --- Regulation --- Cytology. --- Oncology. --- Biochemistry. --- Life sciences. --- Vertebrates. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Life Sciences, general. --- Biosciences --- Sciences, Life --- Science --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Cell biology. --- Cancer research. --- Cancer research