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Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.

Metastasis. --- Cancer cells --- Motility. --- Cancer cell motility --- Motility of cancer cells --- Biomechanics --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Dissemination --- Metastasis --- Oncology. --- Oncology  . --- Medicine. --- Life sciences. --- Cancer Research. --- Biomedicine general. --- Life Sciences, general. --- Biosciences --- Sciences, Life --- Science --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Tumors --- Health Workforce --- Cancer research. --- Biomedicine, general. --- Cancer research

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Since the IMF launched the data standards initiatives a decade ago, 145 of its 184 member countries have participated. This 80 percent participation rate reaffirms the importance countries place on data transparency in the globalized economy, which the initiatives promote. The wide participation can be attributed to the consultative process that has allowed for the development of a coherent program that takes account of countries' capabilities, delineates clear responsibilities between the IMF and participating countries, and establishes effective monitoring procedures to ensure the credibility of the standards for policymakers, capital markets, and the general public. The approach has also provided checks and balances and fostered accountability. The initiatives may provide insights for the promotion of similar international standards.

Disclosure of information. --- Economic indicators -- Standards. --- Electronic books. -- local. --- Finance -- Statistics -- Standards. --- International Monetary Fund. --- Finance --- Business & Economics --- International Finance --- Economic indicators --- Standards. --- Business indicators --- Indicators, Business --- Indicators, Economic --- Leading indicators --- Funding --- Funds --- Information, Disclosure of --- Internationaal monetair fonds --- International monetary fund --- Economic history --- Quality of life --- Economic forecasting --- Index numbers (Economics) --- Social indicators --- Economics --- Currency question --- Truthfulness and falsehood --- Statistics --- Data Transmission Systems --- Methodology for Collecting, Estimating, and Organizing Macroeconomic Data --- Data Access --- Data Collection and Data Estimation Methodology --- Computer Programs: Other --- Data capture & analysis --- Econometrics & economic statistics --- Special Data Dissemination Standard (SDDS) --- Dissemination Standards Bulletin Board (DSBB) --- Financial statistics --- Data dissemination --- Data transmission systems --- Databases --- Singapore

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Indians of North America --- Financing, Government --- Government Programs --- Communication Barriers. --- Financing, Organized --- Indians, North American. --- Information Dissemination --- Inuit. --- Health and hygiene --- organization & administration. --- methods. --- United States. --- Rules and practice.

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The effects of the IMF's data standards initiatives on sovereign borrowing costs in private capital markets are investigated for 26 emerging market and developing countries. Stable and significant panel econometric estimates indicate that subscription to the Special Data Dissemination Standard (SDDS) reduces launch spreads by an average of 20 percent while participation in the General Data Dissemination System (GDDS) reduces spreads for those countries with access to capital markets by an average of 8 percent. These estimates correspond to discounts of some 50 and 20 basis points, respectively. Evidence of similar discounts is also found when launch yields are analyzed.

Capital market. --- Debts, Public. --- Disclosure of information. --- Economic indicators -- Standards. --- Electronic books. -- local. --- Finance -- Statistics -- Standards. --- Finance --- Business & Economics --- Investment & Speculation --- Economic indicators --- Standards. --- Funding --- Funds --- Business indicators --- Indicators, Business --- Indicators, Economic --- Leading indicators --- Information, Disclosure of --- Debts, Government --- Government debts --- National debts --- Public debt --- Public debts --- Sovereign debt --- Capital markets --- Market, Capital --- Economics --- Currency question --- Economic history --- Quality of life --- Economic forecasting --- Index numbers (Economics) --- Social indicators --- Truthfulness and falsehood --- Debt --- Bonds --- Deficit financing --- Financial institutions --- Loans --- Money market --- Securities --- Crowding out (Economics) --- Efficient market theory --- Money and Monetary Policy --- Statistics --- Data Transmission Systems --- Methodology for Collecting, Estimating, and Organizing Macroeconomic Data --- Data Access --- Monetary Policy, Central Banking, and the Supply of Money and Credit: General --- Data Collection and Data Estimation Methodology --- Computer Programs: Other --- Data capture & analysis --- Monetary economics --- Econometrics & economic statistics --- Special Data Dissemination Standard (SDDS) --- Credit ratings --- Data dissemination --- Financial statistics --- Data transmission systems --- Costa Rica

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The late eighteenth century witnessed an explosion of intellectual activity in Scotland by such luminaries as David Hume, Adam Smith, Hugh Blair, William Robertson, Adam Ferguson, James Boswell, and Robert Burns. And the books written by these seminal thinkers made a significant mark during their time in almost every field of polite literature and higher learning throughout Britain, Europe, and the Americas. In this magisterial history, Richard B. Sher breaks new ground for our understanding of the Enlightenment and the forgotten role of publishing during that period. The Enlightenment and the Book seeks to remedy the common misperception that such classics as The Wealth of Nations and The Life of Samuel Johnson were written by authors who eyed their publishers as minor functionaries in their profession. To the contrary, Sher shows how the process of bookmaking during the late eighteenth-century involved a deeply complex partnership between authors and their publishers, one in which writers saw the book industry not only as pivotal in the dissemination of their ideas, but also as crucial to their dreams of fame and monetary gain. Similarly, Sher demonstrates that publishers were involved in the project of bookmaking in order to advance human knowledge as well as to accumulate profits. The Enlightenment and the Book explores this tension between creativity and commerce that still exists in scholarly publishing today. Lavishly illustrated and elegantly conceived, it will be must reading for anyone interested in the history of the book or the production and diffusion of Enlightenment thought.

English literature --- Scottish literature --- Publishers and publishing --- Authors and publishers --- Authors, Scottish --- Enlightenment --- Scottish authors --- Scots literature --- British literature --- Inklings (Group of writers) --- Nonsense Club (Group of writers) --- Order of the Fancy (Group of writers) --- Author and publisher --- Publishers and authors --- Publishing contracts --- Authorship --- Contracts --- Book proposals --- Copyright --- Literary agents --- Book publishing --- Books --- Book industries and trade --- Booksellers and bookselling --- Publishing. --- History --- Appreciation. --- Intellectual life --- Law and legislation --- Publishing --- 094.1 <411> --- 094.1 <417 DUBLIN> --- 094.1 <73 PHILADELPHIA> --- 094 "17" --- 820 "17" --- 930.85.48 <41> --- 930.85.48 <41> Cultuurgeschiedenis: Verlichting; Aufklärung--Verenigd Koninkrijk van Groot-Brittannië en Noord-Ierland --- Cultuurgeschiedenis: Verlichting; Aufklärung--Verenigd Koninkrijk van Groot-Brittannië en Noord-Ierland --- 820 "17" Engelse literatuur--18e eeuw. Periode 1700-1799 --- Engelse literatuur--18e eeuw. Periode 1700-1799 --- 094.1 <73 PHILADELPHIA> Oude drukken: bibliografie----Verenigde Staten van Amerika. VSA. USA--PHILADELPHIA --- Oude drukken: bibliografie----Verenigde Staten van Amerika. VSA. USA--PHILADELPHIA --- 094.1 <417 DUBLIN> Oude drukken: bibliografie----Republiek Ierland--DUBLIN --- Oude drukken: bibliografie----Republiek Ierland--DUBLIN --- 094.1 <411> Oude drukken: bibliografie----Europa--Schotland --- Oude drukken: bibliografie----Europa--Schotland --- 094 "17" Oude en merkwaardige drukken. Kostbare en zeldzame boeken. Preciosa en rariora--18e eeuw. Periode 1700-1799 --- Oude en merkwaardige drukken. Kostbare en zeldzame boeken. Preciosa en rariora--18e eeuw. Periode 1700-1799 --- Scottish authors&delete& --- Appreciation --- Book history --- Graphics industry --- anno 1700-1799 --- England --- Scotland --- Ireland --- America --- scottish authors, scotland, united kingdom, britain, ireland, america, 18th century, literature, publication, robert burns, james boswell, adam ferguson, william robertson, hugh blair, david hume, wealth of nations, life samuel johnson, bookmaking, book industry, knowledge, dissemination, philosophy, economics, print culture, nonfiction, history, strahan and cadell, creech, piracy, copyright, reprinting, immigration, london, edinburgh.