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Genomics --- Signal processing --- Genomics. --- Signal processing. --- Genomics --- Signal Transduction

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Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.

Bacteria --- Cell interaction. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Bacterial physiology --- Physiology --- Physiology.

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Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields. This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.

Polyamines. --- Polyamines in the body. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Amines in the body --- Aliphatic compounds --- Amines --- Imines --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.

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Neurologists --- Medical scientists --- Nobel Prizes --- Memory --- Neurobiology --- Cellular signal transduction --- History, 20th Century --- Neurosciences --- Nobel Prize --- history --- Cellular signal transduction. --- Memory. --- Neurobiology. --- Nobel Prizes. --- Kandel, Eric R. --- Neurologists - United States - Biography --- Medical scientists - United States - Biography --- Neurobiology - United States - Personal Narratives --- History, 20th Century - United States - Personal Narratives --- Neurosciences - history - United States - Personal Narratives --- Nobel Prize - United States - Personal Narratives

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Mechanosensing and Mechanochemical Transduction in Extracellular Matrix offers the reader recent information in addition to models of how mechanical information is transduced into genetic and biochemical changes at the cellular and tissue levels. Mechanosensing and Mechanochemical Transduction in Extracellular Matrix is intended to serve as a textbook at the graduate and advanced undergraduate level in a biomedical engineering curriculum. Topics covered include: Structure of Macromolecules That Make Up Tissue Structure Microscopic and Macroscopic Tissue Structures Methods For Analyzing Macromolecular Structure and Physical Properties Self-Assembly of Biological Macromolecules Involved In Mechanotransduction Mechanical Properties of Biological Macromolecules Viscoelastic Properties of Macromolecules and Tissues Models of Mechanical Properties of Tissues Mechanochemical Sensing and Transduction Mechanochemical Transduction and Its Role in Biology Mechanosensing and Mechanochemical Transduction in Extracellular Matrix is essential reading for biomedical engineers, biologists, physicians, health care professionals and other biomedical researchers who are interested in understanding how physical forces affect the biology, physiology and pathophysiology of humans. About the Author: Frederick H. Silver, Ph.D., is an expert on the effect of mechanical forces on extracellular matrix. He has been a faculty member in Biomedical Engineering departments at Boston University, University of Minnesota and Rutgers University. He is currently Professor of Pathology and Laboratory medicine at UMDNJ-Robert Wood Johnson Medical School.

Engineering. --- Biochemical engineering. --- Life sciences. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Biomedical Engineering. --- Biophysics and Biological Physics. --- Biochemical Engineering. --- Life Sciences, general. --- Extracellular matrix. --- Extracellular matrix --- Cellular signal transduction. --- Cell interaction. --- Mechanical properties. --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular control mechanisms --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Information theory in biology --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Matrix, Extracellular --- Connective tissues --- Extracellular space --- Biomedical Engineering and Bioengineering. --- Biological and Medical Physics, Biophysics. --- Biosciences --- Sciences, Life --- Science --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cell interactions --- Cellular signal transduction --- macromolecule --- mechanochemical --- mechanosensing --- Mechanical properties --- Biological physics --- Biology --- Medical sciences --- Physics