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Restorative therapies in Parkinson's disease
Authors: ---
ISBN: 1280613815 9786610613816 0387328238 038729984X 1489995226 Year: 2006 Publisher: New York, NY : Springer,

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Abstract

Parkinson’s disease is a common and devastating progressive disorder that primarily affects motor function. In this exciting and timely book, novel approaches to repairing the parkinsonian brain are described by some of the world’s leading scientists and clinicians in the field. Dealing with cutting-edge research, it covers several important topics including medical ethics, clinical trial design, stem cell biology, intracerebral transplantation, brain imaging, neurotrophic factors and neural regeneration. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic. Restorative therapies in Parkinson’s disease have pioneered translational research in the area of brain repair for close to three decades. This book clearly shows that research in Parkinson’s disease continues to play a leading role and can provide a model for how functional restoration might be achieved in several brain disorders in the future.

Oxidative stress and neuroprotection
Authors: ---
ISBN: 1280727039 9786610727032 3211333282 3211333274 3709117364 3211333266 Year: 2006 Publisher: New York : Springer,

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Abstract

This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.

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