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Limpact de linfection papillomavirus (HPV) est considrable. Plus dune femme sur deux a t expose aux HPV durant sa vie et 10 % environ feront une infection chronique. Parmi elles, 20 % dvelopperont un cancer du col en labsence ou par dfaillance du dpistage. En France, linfection HPV risque provoque 80 000 lsions prcancreuses, 3 400 cancers du col utrin et le dcs de 1 000 femmes tous les ans. Le dpistage par frottis ralis un rythme rgulier et selon des normes de qualit a entran une diminution significative de lincidence et de la mortalit ces vingt dernires annes. Cependant, malgr ce succs consid
Papillomaviruses. --- Papillomavirus diseases. --- HPV (Virus) --- Human papilloma virus --- Human wart virus --- Infectious human wart virus --- Papilloma viruses --- Papillomaviridae --- Papillomavirus --- Papovaviruses --- Wart virus --- Oncogenic DNA viruses --- Papillomavirus infections --- Virus diseases
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Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.
Polyomavirus infections. --- Polyomaviruses. --- Papovaviruses --- Polyoma virus --- Polyomavirus --- Polyomaviridae --- Oncogenic DNA viruses --- Polyomavirus diseases --- Virus diseases --- Immunology. --- Emerging infectious diseases. --- Pathology. --- Neurology. --- Oncology . --- Infectious Diseases. --- Oncology. --- Tumors --- Medicine --- Nervous system --- Neuropsychiatry --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Infectious diseases. --- Neurology . --- Communicable diseases. --- Contagion and contagious diseases --- Contagious diseases --- Infectious diseases --- Microbial diseases in human beings --- Zymotic diseases --- Infection --- Epidemics
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Human papillomaviruses (HPV) are an important class of pathogens responsible for a variety of diseases, including cervical cancer, the second most commonly found female cancer worldwide. In Human Papillomaviruses: Methods and Protocols, leading basic researchers and clinical scientists describe in detail a wide variety of established and cutting-edge techniques they have developed to study the lifecycle and biological properties of this formidable virus. The authors use these readily reproducible methods, ranging from PCR to propagation of HPV in vitro, to detect and type papillomavirus infections, study the papillomavirus lifecycle, and to produce and functionally analyze papillomavirus proteins. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Authoritative and highly practical, Human Papillomaviruses: Methods and Protocols offers both novice and experienced investigators a set of highly successful analytical tools for unlocking the secrets of the human papillomaviruses and their pathologies.
Papillomavirus diseases --- Papillomaviruses --- HPV (Virus) --- Human papilloma virus --- Human wart virus --- Infectious human wart virus --- Papilloma viruses --- Papillomaviridae --- Papillomavirus --- Papovaviruses --- Wart virus --- Papillomavirus infections --- Medicine. --- Medical microbiology. --- Infectious diseases. --- Biomedicine. --- Medical Microbiology. --- Infectious Diseases. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Oncogenic DNA viruses --- Virus diseases --- Microbiology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms
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