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The book gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision. Pathways and structures of early and late folding events and the transition state structures of fast- and ultrafast-folding proteins can now be studied in far more detail. Important techniques include biophysical, chemical, molecular biological and mathematical methods, in particular protein engineering, Phi-value analysis, time-resolved circular dichroism, optical triggers and pulsed infrared LASER methods, pressure and temperature jump, ultrafast mixing, stopped flow and quenched flow, dielectric relaxation and electric-field-jump, acoustic relaxation, fluorescence- and isotope-labeling, H/D exchange methods, NMR line broadening and stopped-flow NMR, transition state theory, solutions of rate equations, and evolutionary computer programming. Protein Folding Kinetics - Biophysical Methods is written for students and researchers in biochemistry, biophysics, and related fields. Special features in the second edition: • Includes detailed information and 12 color figures on the high resolution of folding transition states. • Discusses structural determinants of the rate of protein folding on a timescale from microseconds to seconds. • Provides information on self-evolving computer programs for protein-folding simulations and protein-structure predictions.

Protein folding. --- Chemical kinetics. --- Chemical reaction, Kinetics of --- Chemical reaction, Rate of --- Chemical reaction, Velocity of --- Chemical reaction rate --- Chemical reaction velocity --- Kinetics, Chemical --- Rate of chemical reaction --- Reaction rate (Chemistry) --- Velocity of chemical reaction --- Chemical affinity --- Reactivity (Chemistry) --- Folding of proteins --- Proteins --- Folding --- Conformation --- Biochemistry. --- Biotechnology. --- Food science. --- Protein Science. --- Biochemistry, general. --- Biological and Medical Physics, Biophysics. --- Food Science. --- Science --- Chemical engineering --- Genetic engineering --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Proteins . --- Biophysics. --- Biological physics. --- Food—Biotechnology. --- Biological physics --- Physics --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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This is a new undergraduate textbook on physical chemistry by Horia Metiu published as four separate paperback volumes. These four volumes on physical chemistry combine a clear and thorough presentation of the theoretical and mathematical aspects of the subject with examples and applications drawn from current industrial and academic research. By using the computer to solve problems that include actual experimental data, the author is able to cover the subject matter at a practical level. The books closely integrate the theoretical chemistry being taught with industrial and laboratory practice. This approach enables the student to compare theoretical projections with experimental results, thereby providing a realistic grounding for future practicing chemists and engineers. Each volume of Physical Chemistry includes Mathematica ; and Mathcad ; Workbooks on CD-ROM. Metiu's four separate volumes-Thermodynamics, Statistical Mechanics, Kinetics, and Quantum Mechanics-offer built-in flexibility by allowing the subject to be covered in any order. These textbooks can be used to teach physical chemistry without a computer, but the experience is enriched substantially for those students who do learn how to read and write Mathematica ; or Mathcad ; programs. A TI-89 scientific calculator can be used to solve most of the exercises and problems. ; Mathematica is a registered trademark of Wolfram Research, Inc. ; Mathcad is a registered trademark of Mathsoft Engineering & Education, Inc.

Quantum theory --- Théorie quantique --- Mathematics --- Textbooks --- Problems, exercises, etc. --- Mathématiques --- Manuels d'enseignement supérieur --- Problèmes et exercices --- 541.12 --- 541.1 --- Chemical mechanics --- Physical chemistry --- 544.18 --- Quantum chemistry --- Chemical kinetics --- 541.1 Physical chemistry --- 544.18 Quantum chemistry --- 541.12 Chemical mechanics --- Théorie quantique --- Mathématiques --- Manuels d'enseignement supérieur --- Problèmes et exercices --- Cinétique chimique --- gassen --- entropie --- enthalpie --- hoofdwetten thermodynamica --- elektrolyten --- Thermodynamique --- Manuels --- 536.7 --- 536.7 Thermodynamics. Energetics --- Thermodynamics. Energetics --- Thermodynamics --- Chemistry, Physical and theoretical --- Dynamics --- Mechanics --- Physics --- Heat --- Heat-engines --- Quantum dynamics --- Quantum mechanics --- Quantum physics --- Chemical reaction, Kinetics of --- Chemical reaction, Rate of --- Chemical reaction, Velocity of --- Chemical reaction rate --- Chemical reaction velocity --- Kinetics, Chemical --- Rate of chemical reaction --- Reaction rate (Chemistry) --- Velocity of chemical reaction --- Chemical affinity --- Reactivity (Chemistry) --- Statistical mechanics --- Mechanics, Analytic --- Quantum statistics --- Statistical physics --- Physicochemistry --- fysicochemie --- thermodynamica --- Mécanique statistique --- Chimie physique et théorique --- Textbooks. --- Statistical mechanics - Textbooks --- Chemistry, Physical and theoretical - Problems, exercises, etc. --- Chemical kinetics - Mathematics - Textbooks --- Chemical kinetics - Problems, exercises, etc. --- Thermodynamics - Textbooks.