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Erythropoietin --- Anemia --- Drugs --- Physiological aspects. --- Treatment. --- Effectiveness.

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This text represents multidisciplinary and international efforts and a combination of research and service. Containing information for patients and families, this volume will be useful to those helping children and their families through the treatment, recovery and grieving process.

Cancer in children. --- Sickle cell anemia in children. --- Cancer in children --- Childhood cancer --- Pediatric cancer --- Tumors in children --- Anemia in children --- Psychological aspects. --- Sickle cell anemia in children

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Molecular Mechanisms of Fanconi Anemia will give research students a platform for further investigation, and act as a source of information regarding experimental design. Clinicians will find this title useful for its comprehensive description of Fanconi Anemia and information on the latest molecular theories underlying its causes.

Fanconi's anemia --- Genetic aspects. --- Molecular aspects. --- Fanconi anemia --- Fanconi's pancytopenia --- Aplastic anemia --- Genetic disorders --- Medicine. --- Human genetics. --- Immunology. --- Molecular Medicine. --- Human Genetics. --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Why do racial and ethnic controversies become attached, as they often do, to discussions of modern genetics? How do theories about genetic difference become entangled with political debates about cultural and group differences in America? Such issues are a conspicuous part of the histories of three hereditary diseases: Tay-Sachs, commonly identified with Jewish Americans; cystic fibrosis, often labeled a "Caucasian" disease; and sickle cell disease, widely associated with African Americans. In this captivating account, historians Keith Wailoo and Stephen Pemberton reveal how these diseases -- fraught with ethnic and racial meanings for many Americans -- became objects of biological fascination and crucibles of social debate. Peering behind the headlines of breakthrough treatments and coming cures, they tell a complex story: about different kinds of suffering and faith, about unequal access to the promises and perils of modern medicine, and about how Americans consume innovation and how they come to believe in, or resist, the notion of imminent medical breakthroughs. With Tay-Sachs, cystic fibrosis, and sickle cell disease as a powerful backdrop, the authors provide a glimpse into a diverse America where racial ideologies, cultural politics, and conflicting beliefs about the power of genetics shape disparate health care expectations and experiences.&

Genetic disorders --- Ethnic groups --- Tay-Sachs disease --- Cystic fibrosis --- Sickle cell anemia --- Research --- Moral and ethical aspects --- Diseases --- Genetic aspects --- Genetic Diseases, Inborn --- Anemia, Sickle Cell. --- Cystic Fibrosis. --- Health Services Accessibility. --- Tay-Sachs Disease. --- #SBIB:316.334.3M11 --- #SBIB:316.334.3M51 --- Amaurotic familial idiocy --- Amaurotic family idiocy --- Gangliosidosis GM2 type 1 --- GM2 gangliosidosis, Type 1 --- Hexosaminidase A deficiency (Tay-Sachs) --- Sachs disease --- Type 1 GM2 gangliosidosis --- Gangliosidoses --- Access to health care --- Accessibility of health services --- Availability of health services --- Medical care --- CF (Disease) --- Fibrocystic disease of pancreas --- Mucoviscidosis --- Pancreatic cystic fibrosis --- Fibrosis --- Lungs --- Pancreas --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Ethnic identities --- Ethnic nations (Ethnic groups) --- Groups, Ethnic --- Kindred groups (Ethnic groups) --- Nationalities (Ethnic groups) --- Peoples (Ethnic groups) --- Ethnology --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Medical genetics --- Moral and ethical aspects. --- Diseases. --- Genetic aspects. --- ethnology. --- prevention & control. --- Medische sociologie: concepten en theorieën --- Organisatie van de gezondheidszorg: modellen van therapeutisch handelen --- Access --- Ethnology. --- Prevention & control. --- Research&delete& --- Genetic disorders - Research - Moral and ethical aspects --- Ethnic groups - Diseases --- Tay-Sachs disease - Genetic aspects --- Cystic fibrosis - Genetic aspects --- Sickle cell anemia - Genetic aspects --- Droit médical

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Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

Anemia. --- Erythropoiesis. --- Erythropoietin. --- Recombinant erythropoietin. --- Erythropoiesis --- Erythropoietin --- Recombinant erythropoietin --- Anemia --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Hematopoiesis --- Colony-Stimulating Factors --- Hematopoietic Cell Growth Factors --- Glycoproteins --- Cell Differentiation --- Blood Physiological Processes --- Blood Physiological Phenomena --- Proteins --- Cell Physiological Processes --- Cytokines --- Cell Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Intercellular Signaling Peptides and Proteins --- Peptides --- Phenomena and Processes --- Chemicals and Drugs --- Biological Factors --- Treatment --- Treatment. --- Anaemia --- Epoetin --- Epogen (Trademark) --- Genetically engineered erythropoietin --- Genetic engineering --- Medicine. --- Pharmacology. --- Endocrinology. --- Sports medicine. --- Cell biology. --- Biomedicine. --- Pharmacology/Toxicology. --- Cell Biology. --- Sports Medicine. --- Blood --- Recombinant blood proteins --- Colony-stimulating factors (Physiology) --- Hematopoietic growth factors --- Diseases --- Toxicology. --- Cytology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Athletic medicine --- Athletics --- Medicine and sports --- Physical education and training --- Sports --- Sports sciences --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Internal medicine --- Hormones --- Toxicology --- Medical aspects --- Endocrinology . --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect