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This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward. With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress response has been explored. These advances are described

Inositol. --- Inositol phosphates. --- Phosphoinositides. --- Phosphatidylinositides --- Phosphatidylinositol phosphates --- Phospholipids --- Inositol --- Hexose phosphates --- Cyclohexanehexol --- Mesoinositol --- Myoinositol --- Alcohols --- Phosphoinositides --- Sugars --- Vitamin B complex --- Biochemistry. --- Plant physiology. --- Biochemistry, general. --- Plant Biochemistry. --- Plant Physiology. --- Botany --- Plants --- Physiology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Plant biochemistry. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Phytochemicals --- Plant biochemical genetics

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When the kidney fails its intended mission to manage the body’s waste products, physicians must perform multi-level and simultaneous adjustments to replicate kidney function. The management of the body’s absorption, reabsorption, utilization and excretion of calcium and phosphate requires constant fine tuning. Calcium and Phosphate Metabolism Management in Chronic Renal Diseases provides an overview of the state-of-the-art clinical and basic science aspects of abnormal calcium and phosphate metabolism and its management. Chen Hsing Hsu is a Professor of Internal Medicine at the University of Michigan Medical Center, Ann Arbor, Michigan.

Calcium --- Phosphates --- Chronic renal failure. --- Metabolism. --- Chronic kidney failure --- Chronic renal insufficiency --- End-stage kidney disease --- End-stage renal disease --- ESRD (Disease) --- Kidney failure, Chronic --- Renal failure, Chronic --- Renal insufficiency --- Renal insufficiency, Chronic --- Diseases --- Kidneys --- Bone products --- Calcium metabolism --- Nephrology. --- Orthopedics. --- Endocrinology. --- Internal medicine --- Hormones --- Orthopaedics --- Orthopedia --- Surgery --- Endocrinology .