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Although inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. Authoritative and state-of-the-art, Cell Signaling in Vascular Inflammation offers physiologists, molecular and cell biologists, and pharmaceutical scientists a comprehensive survey of the signal transduction pathways in lung vascular cells that illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Vasculitis. --- Cellular signal transduction. --- Inflammation --- Mediators. --- Medicine. --- Vascular surgery. --- Medicine & Public Health. --- Vascular Surgery. --- Vascular surgery --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Inflammatory mediators --- Mediators of inflammation --- Biomolecules --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Angiitis --- Blood-vessels --- Vasculitides --- Diseases --- Surgery.

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Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts. Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.

Membrane Microdomains --- Apoptosis --- Lipids --- Signal Transduction --- Synapses --- Membrane lipids --- Cellular signal transduction --- Lipides membranaires --- Transduction du signal cellulaire --- pathology --- physiology --- metabolism --- Apoptosis. --- Cellular signal transduction. --- Membrane lipids. --- Metabolism --- Physiology --- Lipid Metabolism --- Pathology --- Biochemical Processes --- Nervous System --- Cell Membrane Structures --- Metabolic Phenomena --- Chemicals and Drugs --- Cell Death --- Cell Physiological Processes --- Medicine --- Intercellular Junctions --- Biological Science Disciplines --- Phenomena and Processes --- Natural Science Disciplines --- Biochemical Phenomena --- Cell Membrane --- Cell Physiological Phenomena --- Chemical Processes --- Health Occupations --- Anatomy --- Cellular Structures --- Disciplines and Occupations --- Chemical Phenomena --- Cells --- Cytology --- Animal Biochemistry --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Life sciences. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Membranes (Biology)

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A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding. About the Author: Martin Beckerman, Ph.D. is Senior Scientist at the Center forMartin Beckerman, PhD, is a senior research scientist at the Department of Energy/National Nuclear Security Administration’s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has authored over 130 publications and has been included in 1400 citations.

Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cytology. --- Medicine. --- Biomedical engineering. --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Cell Biology. --- Molecular Medicine. --- Biomedical Engineering and Bioengineering. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Biophysics. --- Biological physics. --- Cell biology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Biological physics --- Physics --- Cellular signal transduction --- 577.35 --- 577.35 Biophysics of living systems --- Biophysics of living systems --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).

Cells -- Morphology -- Congresses. --- Cellular signal transduction -- Congresses. --- Cellular signal transduction --- Cells --- Symporters --- Cell Physiological Phenomena --- Cell Death --- Membrane Glycoproteins --- Peptides --- Proteins --- Membrane Transport Proteins --- Cell Physiological Processes --- Biochemical Processes --- Cytoplasmic Structures --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Membrane Proteins --- Phenomena and Processes --- Biochemical Phenomena --- Cytoplasm --- Chemical Processes --- Ion Pumps --- Chemicals and Drugs --- Carrier Proteins --- Chemical Phenomena --- Intracellular Space --- Cellular Structures --- Anatomy --- Ion Channels --- Intercellular Signaling Peptides and Proteins --- Signal Transduction --- Cytoskeleton --- Sodium-Potassium-Chloride Symporters --- Cell Size --- Apoptosis --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Animal Biochemistry --- Morphology --- Life sciences. --- Human physiology. --- Molecular biology. --- Neurosciences. --- Cell biology. --- Neurobiology. --- Life Sciences. --- Cell Biology. --- Human Physiology. --- Molecular Medicine. --- Life Sciences, general. --- Neurosciences --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Neural sciences --- Neurological sciences --- Medical sciences --- Nervous system --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Human biology --- Physiology --- Human body --- Biosciences --- Sciences, Life --- Science --- Organisms --- Cytology --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians

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Eye Diseases --- Diagnostic Techniques and Procedures --- Light Signal Transduction --- Afferent Pathways --- Sensation Disorders --- Sensation --- Neurobehavioral Manifestations --- Ocular Physiological Processes --- Signal Transduction --- Diagnosis --- Neurologic Manifestations --- Behavior and Behavior Mechanisms --- Ocular Physiological Phenomena --- Psychophysiology --- Neural Pathways --- Nervous System Physiological Processes --- Diseases --- Biochemical Processes --- Nervous System --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Signs and Symptoms --- Phenomena and Processes --- Psychological Phenomena and Processes --- Nervous System Diseases --- Psychiatry and Psychology --- Cell Physiological Processes --- Nervous System Physiological Phenomena --- Cell Physiological Phenomena --- Chemical Processes --- Pathological Conditions, Signs and Symptoms --- Musculoskeletal and Neural Physiological Phenomena --- Anatomy --- Biochemical Phenomena --- Chemical Phenomena --- Perceptual Disorders --- Vision, Ocular --- Visual Pathways --- Diagnostic Techniques, Ophthalmological --- Vision Disorders --- Diagnostic Techniques, Neurological --- Diagnostic Technic, Neurological --- Diagnostic Technics, Neurologic --- Diagnostic Technics, Neurological --- Diagnostic Technique, Neurological --- Diagnostic Techniques, Neurologic --- Neurological Diagnostic Technic --- Neurological Diagnostic Technics --- Neurological Diagnostic Technique --- Neurological Diagnostic Techniques --- Technic, Neurological Diagnostic --- Technics, Neurological Diagnostic --- Technique, Neurological Diagnostic --- Techniques, Neurological Diagnostic --- Diagnostic Technic, Neurologic --- Diagnostic Technique, Neurologic --- Neurologic Diagnostic Technic --- Neurologic Diagnostic Technics --- Neurologic Diagnostic Technique --- Neurologic Diagnostic Techniques --- Technic, Neurologic Diagnostic --- Technics, Neurologic Diagnostic --- Technique, Neurologic Diagnostic --- Techniques, Neurologic Diagnostic --- Day Blindness --- Metamorphopsia --- Vision Disability --- Visual Disorders --- Visual Impairment --- Hemeralopia --- Macropsia --- Micropsia --- Blindness, Day --- Disabilities, Vision --- Disability, Vision --- Disorder, Visual --- Disorders, Visual --- Hemeralopias --- Impairment, Visual --- Impairments, Visual --- Macropsias --- Metamorphopsias --- Micropsias --- Vision Disabilities --- Vision Disorder --- Visual Disorder --- Visual Impairments --- Diagnostic Technic, Ophthalmological --- Diagnostic Technics, Ophthalmologic --- Diagnostic Technics, Ophthalmological --- Diagnostic Technique, Ophthalmological --- Diagnostic Techniques, Ophthalmologic --- Ophthalmological Diagnostic Technic --- Ophthalmological Diagnostic Technics --- Ophthalmological Diagnostic Technique --- Ophthalmological Diagnostic Techniques --- Technic, Ophthalmological Diagnostic --- Technics, Ophthalmological Diagnostic --- Technique, Ophthalmological Diagnostic --- Techniques, Ophthalmological Diagnostic --- Diagnostic Technic, Ophthalmologic --- Diagnostic Technique, Ophthalmologic --- Ophthalmologic Diagnostic Technic --- Ophthalmologic Diagnostic Technics --- Ophthalmologic Diagnostic Technique --- Ophthalmologic Diagnostic Techniques --- Technic, Ophthalmologic Diagnostic --- Technics, Ophthalmologic Diagnostic --- Technique, Ophthalmologic Diagnostic --- Techniques, Ophthalmologic Diagnostic --- Pathway, Visual --- Pathways, Visual --- Visual Pathway --- Light Signal Transduction, Visual --- Ocular Vision --- Visual Light Signal Transduction --- Visual Phototransduction --- Visual Transduction --- Vision --- Phototransduction, Visual --- Transduction, Visual --- Eye --- Ophthalmology --- Visual Perception --- Hemisensory Neglect --- Sensory Neglect --- Somatosensory Discrimination Disorder --- Hemispatial Neglect --- Discrimination Disorder, Somatosensory --- Discrimination Disorders, Somatosensory --- Hemisensory Neglects --- Hemispatial Neglects --- Neglect, Hemisensory --- Neglect, Hemispatial --- Neglect, Sensory --- Neglects, Hemisensory --- Perceptual Disorder --- Sensory Neglects --- Somatosensory Discrimination Disorders --- Perceptual Distortion --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Anatomies --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Symptoms and General Pathology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Symptoms and Signs --- Nervous Systems --- System, Nervous --- Systems, Nervous --- Neural Interconnections --- Interconnection, Neural --- Interconnections, Neural --- Neural Interconnection --- Neural Pathway --- Pathway, Neural --- Pathways, Neural --- Peripheral Nervous System --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Eye Physiology --- Ocular Physiologic Process --- Ocular Physiological Concepts --- Ocular Physiological Phenomenon --- Ocular Physiological Process --- Physiology of the Eye --- Physiology, Ocular --- Visual Physiology --- Ocular Physiologic Processes --- Ocular Physiology --- Concept, Ocular Physiological --- Concepts, Ocular Physiological --- Ocular Physiological Concept --- Phenomena, Ocular Physiological --- Phenomenon, Ocular Physiological --- Physiologic Process, Ocular --- Physiologic Processes, Ocular --- Physiological Concept, Ocular --- Physiological Concepts, Ocular --- Physiological Process, Ocular --- Physiological Processes, Ocular --- Physiology, Eye --- Physiology, Visual --- Process, Ocular Physiologic --- Process, Ocular Physiological --- Processes, Ocular Physiologic --- Processes, Ocular Physiological --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Cognitive Manifestations --- Neurobehavioral Signs and Symptoms --- Cognitive Symptoms --- Signs and Symptoms, Neurobehavioral --- Cognitive Manifestation --- Cognitive Symptom --- Manifestation, Cognitive --- Manifestation, Neurobehavioral --- Manifestations, Cognitive --- Manifestations, Neurobehavioral --- Neurobehavioral Manifestation --- Symptom, Cognitive --- Symptoms, Cognitive --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Sensory Disorders --- Special Senses Disorders --- Sensation Disorder --- Senses Disorder, Special --- Senses Disorders, Special --- Sensory Disorder --- Special Senses Disorder --- Afferent Pathway --- Pathway, Afferent --- Pathways, Afferent --- Phototransduction --- Signal Transduction, Light --- Transduction, Light Signal --- Photoreceptors, Plant --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Sensitivity and Specificity --- Eye Disorders --- Eye Disease --- Eye Disorder --- physiology --- diagnosis --- methods --- Behavior And Behavior Mechanism --- Diagnose --- Diagnostic Testing --- Testing, Diagnostic