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Originally published in 2005, this volume examines the role of steroids and peptides in the regulation of pregnancy and pregnancy outcome, and their long-term effects including possible influences on adult-onset diseases. During pregnancy the placenta acts as a central regulator and coordinator of maternal and fetal physiology, and the onset of labor, through its production and regulation of steroids and peptides. Perturbations to this regulatory system can result in poor pregnancy outcome, such as preterm birth and low birth weight. These in turn are linked to diseases in later life. Intriguingly, many of these regulatory actions of steroids and peptides also occur in the brain. The induction and suppression of peptides by steroids appears to be key to regulatory function in both brain and placenta. These interweaving strands, linking basic science with obstetrics, are all reviewed in depth here producing a fascinating account of an important area of materno-fetal medicine.
Obstetrical endocrinology. --- Steroid hormones --- Peptides --- Maternal-fetal exchange. --- Prenatal influences. --- Disease susceptibility. --- Physiological effect.
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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-
Vitamin D. --- Vitamin D in human nutrition. --- Nutrition --- Calcium regulating hormones --- Steroid hormones --- Vitamins, Fat-soluble --- Vitamin D
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Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Neuroendocrinology. --- Steroid hormones --- Nervous system --- Physiological effect. --- Degeneration --- Endocrine aspects. --- Organs (Anatomy) --- Neurosciences --- Hormonal steroids --- Hormones --- Steroids --- Endocrinology --- Neurology --- Neurohormones --- Neurology. --- Medicine --- Neuropsychiatry --- Diseases --- Neurology .
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Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
Birth control. --- Contraception. --- Contraceptives. --- Intrauterine contraceptives. --- Progestins --- Receptors, Progesterone --- Contraceptive Agents, Female --- Endometrium --- Receptors, Steroid --- Contraceptive Agents --- Hormones --- Uterus --- Receptors, Cytoplasmic and Nuclear --- Genitalia, Female --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Reproductive Control Agents --- Proteins --- Transcription Factors --- Genitalia --- Therapeutic Uses --- Physiological Effects of Drugs --- DNA-Binding Proteins --- Urogenital System --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Anatomy --- Chemical Actions and Uses --- Gynecology & Obstetrics --- Medicine --- Health & Biological Sciences --- Birth control devices --- Contraceptive devices --- Medicine. --- Gynecology. --- Obstetrics. --- Reproductive medicine. --- Medicine & Public Health. --- Obstetrics/Perinatology. --- Reproductive Medicine. --- Medical instruments and apparatus --- Obstetrics/Perinatology/Midwifery. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Maternal-fetal medicine --- Gynaecology --- Generative organs, Female --- Health aspects --- Diseases --- Gynecology .
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Testosterone has inspired dreams-of restored youth, recharged sexual appetites, faster running, quicker thinking, bigger muscles-since it was first synthesized in 1935. This provocative book investigates the complex, bizarre, and sometimes outrageous history of synthetic testosterone and other male hormone therapies. Exploring many little-known social arenas-both inside and outside the medical world-in which these substances are becoming increasingly available and accepted, Testosterone Dreams examines the implications and dangers of their use in professional sports, in the workplace, in our sex lives, and beyond. Testosterone Dreams tells the story of testosterone's growing and sometimes concealed influence in our culture over the past 70 years. It explores such controversial topics as the invention and marketing of the male menopause, the disturbing history of hormonal and other medical treatments aimed at boosting or suppressing women's sexuality, and hormone doping in sporting events such as the Tour de France and the Olympics, and in Major League Baseball. It brings to light the hidden use of hormone doping by policemen, soldiers, and other workers in a variety of jobs. It also discusses the burgeoning steroid use in the gay community and its relation to AIDS, and takes a hard look at the pharmaceutical industry's promotional campaigns to create new markets for testosterone products. Testosterone Dreams is the first book to bring together the whole story of testosterone and to consider its social and ethical implications: Where does therapy end and performance enhancement begin? How are changing medical technologies affecting how we think about our identities as men and women and the elusive goal of "well-being"? This book will be essential reading as we move inexorably toward the wide-open, libertarian pharmacology that is now making these drug regimes available to a wider and wider clientele.
Testosterone. --- Hormone therapy. --- Menopause --- Testosterone --- Longevity. --- Aphrodisiacs. --- Love philters --- Love philtres --- Love potions --- Philters --- Philtres --- Drugs --- Life, Long --- Life extension --- Life span prolongation --- Long life --- Prolongation of life span --- Age --- Health --- Life spans (Biology) --- Old age --- Androgens --- Estrogen replacement therapy for menopause --- Hormone replacement therapy for menopause --- Hormone therapy --- Endocrine therapy --- Hormones --- Therapeutics --- Therapeutic use. --- Physiological effect. --- Estrogen replacement therapy --- Hormone replacement therapy --- Therapeutic use --- Aphrodisiacs --- Longevity --- 613.83 --- 796.011.5 --- 796.011.5 Ethiek van de sport. Fair play --- Ethiek van de sport. Fair play --- 613.83 Narcotics --- Narcotics --- Physiological effect --- 20th century. --- aids. --- aphrodisia. --- athletes. --- controversial topic. --- ethics of testosterone use. --- hormone dipping. --- hormone doping. --- hormone therapy. --- hormone treatments. --- male hormones. --- masculinity. --- medical community. --- medical technologies. --- medical treatments. --- men and women. --- muscle building. --- pharmacology. --- professional sports. --- scientists. --- sexual appetites. --- sexuality. --- social perspective. --- social sciences. --- soldiers. --- steroid use. --- synthetic testosterone. --- testosterone.
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Cell metabolism --- Cells --- Metabolic Diseases --- Homeostasis --- metabolism --- Metabolic Diseases. --- Homeostasis. --- Cellules --- Cell metabolism. --- Métabolisme cellulaire. --- metabolism. --- Métabolisme --- Autoregulation --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Metabolism --- Cell --- Cell Biology --- Cellular control mechanisms --- Métabolisme cellulaire. --- Métabolisme --- Cytology --- cells. --- metabolic diseases. --- homeostasis. --- biochemistry --- physiology --- anabolism --- biocatalysis --- biosynthesis --- carbohydrate metabolism --- carbon metabolism --- catabolism --- catabolite repression --- copper metabolism --- dealkylation --- energy metabolism --- hormone metabolism --- lipid metabolism --- metabolic detoxification --- metabolic sequestration --- mineral metabolism --- nitrogen metabolism --- pharmacokinetics --- protein metabolism --- steroid metabolism --- vitamin metabolism --- water metabolism --- metabolic flux analysis --- metabolic studies --- metabolites --- metabolome --- metabolomics --- oxidative stress --- cell biology --- acinar cells --- adipocytes --- aleurone cells --- antigen-presenting cells --- bacteriocytes --- blood cells --- bone marrow cells --- bundle sheath cells --- chondrocytes --- chromaffin cells --- chromatophores --- coelomocytes --- cultured cells --- endothelial cells --- epithelial cells --- eukaryotic cells --- fibroblasts --- germ cells --- giant cells --- gonadotropic cells --- granulosa cells --- guard cells --- hemocytes --- hepatocytes --- islets of Langerhans --- keratinocytes --- kidney cells --- Leydig cells --- luteal cells --- mast cells --- myocytes --- neoplasm cells --- neurosecretory cells --- nurse cells --- osteoblasts --- osteoclasts --- phagocytes --- plant root cells --- prokaryotic cells --- Schwann cells --- Sertoli cells --- somatic cells --- splenocytes --- spores --- stem cells --- stromal cells --- tenocytes --- teratocytes --- thecal cells --- vegetative cells --- artificial cells --- cell transplantation --- cell viability --- cellular microenvironment --- physiological regulation --- autoregulation --- glucagon-like peptide 2 --- glucoregulation --- glucose tolerance tests --- metabolic disorders --- noninfectious diseases --- acidosis --- alkalosis --- calcinosis --- carbohydrate metabolism disorders --- dehydration (animal physiology) --- developmental orthopedic disease --- diabetes --- hypercalcemia --- hyperinsulinemia --- hyperkalemia --- hyperketonemia --- hypocalcemia --- hypokalemia --- hypomagnesemia --- hyponatremia --- inherited metabolic diseases --- iron overload --- ketonemia --- ketonuria --- lipid metabolism disorders --- osteomalacia --- refeeding syndrome --- uremia --- malnutrition --- Metabolisme cel·lular --- Citologia --- Homeòstasi
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