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Physical methods for diagnosis

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Physical methods for diagnosis --- Gastroenterology

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The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section. The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications.

Physical methods for diagnosis --- radiologie --- medische beeldvorming

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Perfect for the non-specialist, this pocket guide focuses on common injuries and those abnormalities that are frequently overlooked or misinterpreted in the emergency department...and gives key indicators when a radiologist should be consulted. Using a concise and systematic approach, it explains how to examine and accurately interpret x-rays. Each chapter focuses on the basic radiographs required, important anatomy, normal variants, a system for inspecting suggested views, types of injury, and ends with a summary of key points. Highlights common sources of error and diagnostic difficulty. Emphasizes pitfalls and associated abnormalities. Provides a summary of key points at the end of each chapter for a quick overview of the most important features. Accompanies radiographs with line-drawings to explain difficult concepts.

Physical methods for diagnosis --- Human medicine

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Birds --- Physical methods for diagnosis --- Neuropathology