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Neurosurgical Procedures. --- Nervous System Diseases --- Nervous system --- Neurochirurgie --- surgery. --- Surgery.

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Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Nervous system --- Degeneration. --- Diseases --- Treatment.

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Nature Reviews Neurology is a peer-reviewed journal for neurologists and affiliated health care professionals. The journal delivers timely interpretations of key scientific developments in neurology and related areas of study. Nature Reviews Neurology is published monthly in print and online and includes commissioned news, commentary and opinion pieces and comprehensive reviews. Articles are subject to rigorous peer-review and/or review by in-house editors. Topics covered include pathogenesis, prevention, diagnosis and treatment of disease or impaired function of the central and peripheral nervous systems, including neurodevelopmental, neurodegenerative and neuropsychiatric disorders.

Neurology --- Nervous system --- Nervous System Diseases --- Neurologie --- Système nerveux --- Diseases. --- Maladies. --- Nervous System Diseases.

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Central Nervous System Neoplasms. --- Central Nervous System Neoplasms, Primary --- Central Nervous System Tumors --- Primary Central Nervous System Neoplasms --- Tumors, Central Nervous System --- Neoplasms, Central Nervous System --- Central nervous system --- Cancer. --- Central Nervous System Neoplasms --- Cancer --- CNS Neoplasms --- CNS Neoplasm --- Neoplasm, CNS --- Neoplasms, CNS --- Central Nervous System Neoplasm --- Central Nervous System Tumor --- Primary Central Nervous System Neoplasm

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This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and

Metalloproteinases. --- Central nervous system. --- Extracellular matrix proteins. --- Matrix proteins --- Proteins --- Nervous system, Central --- Nervous system --- Metalloproteases --- Metalloenzymes --- Proteinase