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Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

Neoplasms --- Drug Therapy, Combination. --- Cancer --- Apoptosis. --- Apoptose --- drug therapy. --- Chemotherapy. --- Treatment. --- Chimiothérapie --- Traitement --- Apoptosis --- Drug Therapy, Combination --- Chemotherapy --- Treatment --- drug therapy --- Cancer -- Chemotherapy. --- Cancer -- Treatment. --- Drug Therapy --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell death --- Antineoplastic agents --- Oncology  . --- Cancer - Chemotherapy --- Cancer - Treatment --- Neoplasms - drug therapy

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Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications.

Camptothecin --- Neoplasms --- Antineoplastic Agents, Phytogenic --- Camptothecin. --- Cancer --- therapeutic use. --- drug therapy. --- analogs & derivatives. --- pharmacology. --- Chemotherapy. --- Chimiothérapie --- Chemotherapy --- therapeutic use --- drug therapy --- analogs and derivatives --- pharmacology --- Cancer -- Chemotherapy. --- Alkaloids --- Diseases --- Therapeutics --- Antineoplastic Agents --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Heterocyclic Compounds --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Pharmacology --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Antiviral agents --- Treatment --- Oncology  . --- Cancer - Chemotherapy --- Camptothecin - therapeutic use --- Neoplasms - drug therapy --- Antineoplastic Agents, Phytogenic - therapeutic use --- Camptothecin - analogs and derivatives --- Camptothecin - pharmacology