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Meristematic cells in plants become the many different types of cells found in a mature plant. This is achieved by a selective response to chemical signals both from neighbouring cells and distant tissues. It is these responses that shape the plant, its time of flowering, the sex of its flowers, its length of survival or progress to senescence and death. How do plants achieve this? This treatise addresses this question using well-chosen examples to illustrate the concept of target cells. The authors discuss how each cell has the ability to discriminate between different chemical signals, determining which it will respond to and which it will ignore. The regulation of gene expression through signal perception and signal transduction is at the core of this selectivity and the Target Cell concept. This volume will serve as a valuable reference for all researchers working in the field of plant developmental biology.

Plant cellular signal transduction. --- Plant hormones. --- Plants --- Plant and Crop Sciences. Botany --- Development. --- Plant Development. --- Development of plants --- Plant development --- Developmental biology --- Growth (Plants) --- Cellular signal transduction --- Plant cellular control mechanisms --- Hormones (Plants) --- Phytohormones --- Hormones --- Phytochemicals --- Plant regulators --- Ontogeny

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Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Liver --- Cellular signal transduction. --- Diseases. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Surgery. --- Clinical medicine. --- Gastroenterology. --- Surgical oncology. --- Internal medicine. --- Hepatology. --- Surgical Oncology. --- Internal Medicine. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Internal medicine --- Digestive organs --- Medicine, Clinical --- Medicine --- Surgery, Primitive --- Medicine, Internal --- Excision --- Treatment --- Diseases --- Gastroenterology . --- Gastroenterology

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A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding. About the Author: Martin Beckerman, Ph.D. is Senior Scientist at the Center forMartin Beckerman, PhD, is a senior research scientist at the Department of Energy/National Nuclear Security Administration’s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has authored over 130 publications and has been included in 1400 citations.

Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cytology. --- Medicine. --- Biomedical engineering. --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Cell Biology. --- Molecular Medicine. --- Biomedical Engineering and Bioengineering. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Biophysics. --- Biological physics. --- Cell biology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Biological physics --- Physics --- Cellular signal transduction --- 577.35 --- 577.35 Biophysics of living systems --- Biophysics of living systems --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death