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Neonatology and Blood Transfusion Proceedings of the Twenty-Eighth International Symposium on Blood Transfusion, Groningen, NL, Organized by the Sanquin Division Blood Bank North-East, Groningen It is in many ways fitting that the last of these international symposia on blood transfusion should end with neonatal blood transfusion. The most fragile, least well studied and most at risk population requires special care and concern. We need to expand our knowledge of their unique physiology, biochemical pathways and in planning treatment and interventions, always "do no harm." This proceedings of the last Groningen symposium presents a wealth of information on developmental immunology, the molecular basis of haematopoeisis, physiological basis of bleeding and thrombosis, transfusion risks and benefits and lastly, future therapies. Infants provide us with much to learn but in turn they will be the providers of (through cord blood) and the recipients of (through cellular engineering) the best that science can offer. Translational research, which has been the thrust of these presentations for 28 years, will benefit them in a way that no scientist could have ever predicted.

Medicine & Public Health. --- Hematology. --- Blood Transfusion Medicine. --- Medicine. --- Blood transfusion. --- Médecine --- Hématologie --- Blood transfusion -- Methods -- Congresses. --- Neonatology. --- Infant, Newborn --- Blood Transfusion --- Infant --- Biological Therapy --- Age Groups --- Therapeutics --- Persons --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Named Groups --- Hematologic Diseases --- Pathology --- Medicine --- Health & Biological Sciences --- Hematology --- Neonatology --- Neonatal pediatrics --- Haematology --- Perinatology --- Newborn infants --- Internal medicine --- Blood --- Diseases --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Transfusion committees

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Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death

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Targeted therapies are the focus of much research in oncology. Encouraging results from the development of new monoclonal antibodies are revolutionizing clinical therapies and this is particularly the case for haematologic malignancies. The advent of immunotherapy heralds a new era particularly for patients who are refractory to more traditional therapies. Impressive results are evident using monoclonal antibodies (mAb) that a) bind with high specificity to cell-surface antigens, resulting in targeted killing of the malignant cells or b) are conjugated to radioisotopes, toxins, enzymes or drug

Cancer. --- Lymphatics. --- Lymphoma. --- Lymphoma --- Immunotherapy --- Lymphoproliferative Disorders --- Neoplasms by Histologic Type --- Immunomodulation --- Lymphatic Diseases --- Biological Therapy --- Immunoproliferative Disorders --- Neoplasms --- Immune System Diseases --- Diseases --- Therapeutics --- Hemic and Lymphatic Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases of Immune System --- Immune Diseases --- Immunological Diseases --- Immune Disorders --- Immunologic Diseases --- Disease, Immune --- Disease, Immune System --- Disease, Immunologic --- Disease, Immunological --- Diseases, Immune --- Diseases, Immune System --- Diseases, Immunologic --- Diseases, Immunological --- Disorder, Immune --- Disorders, Immune --- Immune Disease --- Immune Disorder --- Immune System Disease --- Immunologic Disease --- Immunological Disease --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Sarcoma, Germinoblastic --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Germinoblastomas --- Lymphomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Reticulolymphosarcomas --- Sarcomas, Germinoblastic --- Disorder, Immunoproliferative --- Disorders, Immunoproliferative --- Immunoproliferative Disorder --- Biologic Therapy --- Biotherapy --- Therapy, Biological --- Biologic Therapies --- Biological Therapies --- Biotherapies --- Therapies, Biologic --- Therapies, Biological --- Therapy, Biologic --- Lymphatism --- Status Lymphaticus --- Disease, Lymphatic --- Diseases, Lymphatic --- Lymphatic Disease --- Immunomodulatory Therapy --- Immunomodulations --- Immunomodulatory Therapies --- Therapies, Immunomodulatory --- Therapy, Immunomodulatory --- Histological Type of Neoplasm --- Histological Types of Neoplasms --- Neoplasms by Histological Type --- Neoplasm Histological Type --- Neoplasm Histological Types --- Neoplasms Histological Type --- Neoplasms Histological Types --- Duncan Disease --- Epstein-Barr Virus Infection, Familial Fatal --- Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males --- Familial Fatal Epstein-Barr Infection --- Immunodeficiency 5 --- Immunodeficiency, X-Linked Progressive Combined Variable --- Lymphoproliferative Disease, X-Linked --- Lymphoproliferative Syndrome, X-Linked, 1 --- Purtilo Syndrome --- X-Linked Lymphoproliferative Disease --- X-Linked Lymphoproliferative Disorder --- Duncan's Syndrome --- X-Linked Lymphoproliferative Syndrome --- Disease, Duncan --- Disease, X-Linked Lymphoproliferative --- Diseases, X-Linked Lymphoproliferative --- Disorder, Lymphoproliferative --- Disorder, X-Linked Lymphoproliferative --- Disorders, Lymphoproliferative --- Disorders, X-Linked Lymphoproliferative --- Epstein Barr Virus Induced Lymphoproliferative Disease In Males --- Epstein Barr Virus Infection, Familial Fatal --- Familial Fatal Epstein Barr Infection --- Immunodeficiency 5s --- Immunodeficiency, X Linked Progressive Combined Variable --- Lymphoproliferative Disease, X Linked --- Lymphoproliferative Diseases, X-Linked --- Lymphoproliferative Disorder --- Lymphoproliferative Disorder, X-Linked --- Lymphoproliferative Disorders, X-Linked --- Lymphoproliferative Syndrome, X-Linked --- Lymphoproliferative Syndromes, X-Linked --- Purtilo Syndromes --- Syndrome, Purtilo --- Syndrome, X-Linked Lymphoproliferative --- Syndromes, Purtilo --- Syndromes, X-Linked Lymphoproliferative --- X Linked Lymphoproliferative Disease --- X Linked Lymphoproliferative Disorder --- X Linked Lymphoproliferative Syndrome --- X-Linked Lymphoproliferative Diseases --- X-Linked Lymphoproliferative Disorders --- X-Linked Lymphoproliferative Syndromes --- Immunotherapies --- therapy --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Hematologic Neoplasms --- Amyloidosis --- Immunity, Active --- Immunologic Techniques --- Immune System Disorders --- Disorder, Immune System --- Immune System Disorder --- Blood and Lymphatic System Disorders --- Combined Antibody Therapeutics --- Diagnostic Techniques and Procedures --- Immunotherapy. --- Lymphoproliferative Disorders. --- Neoplasms by Histologic Type. --- Immunomodulation. --- Lymphatic Diseases. --- Biological Therapy. --- Immunoproliferative Disorders. --- Neoplasms. --- Immune System Diseases. --- Disease. --- Therapeutics. --- Hemic and Lymphatic Diseases. --- Diagnostic Techniques and Procedures.