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ISBN: 1281329193 9786611329198 3540263632 3540230904 3642421881 Year: 2005 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,
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The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
B cells. --- Lymphocytes. --- Nongranular leucocytes --- Leucocytes --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Antigen presenting cells --- Lymphocytes --- Immunology. --- Immunobiology --- Life sciences --- Serology
ISBN: 1280804246 9786610804245 0387274456 0306482371 1441934383 Year: 2005 Publisher: New York, NY : Springer US : Imprint: Springer,
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Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".
B cells --- Macrophages --- Dendritic cells --- Natural immunity. --- Cellular immunity. --- Receptors. --- Cell-mediated immunity --- Cellular immunology --- Clonal selection theory --- Immune response --- Immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Follicular dendritic cells --- Interdigitating cells --- Antigen presenting cells --- Lymphoid tissue --- Histiocytes --- Mononuclear phagocytes --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Lymphocytes --- Cytology. --- Immunology. --- Cell Biology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.
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ISSN: 19380712 Year: 2005 Publisher: [Dallas, TX] : [CIG Media Group],
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Lymphomas --- Multiple myeloma --- Lymphoma. --- Multiple Myeloma. --- Lymphomas. --- Multiple myeloma. --- Kahler's disease --- Plasma cell myeloma --- Germinoblastomas --- Immunoblastomas --- Lymphoma --- Non-Hodgkin's lymphoma --- Reticulolymphosarcomas --- Sarcoma, Germinoblastic --- Sarcoma, Immunoblastic --- Kahler Disease --- Myeloma, Multiple --- Myeloma-Multiple --- Myelomatosis --- Plasma Cell Myeloma --- Myeloma, Plasma-Cell --- Cell Myeloma, Plasma --- Cell Myelomas, Plasma --- Disease, Kahler --- Multiple Myelomas --- Myeloma Multiple --- Myeloma, Plasma Cell --- Myeloma-Multiples --- Myelomas, Multiple --- Myelomas, Plasma Cell --- Myelomas, Plasma-Cell --- Myelomatoses --- Plasma Cell Myelomas --- Plasma-Cell Myeloma --- Plasma-Cell Myelomas --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Sarcomas, Germinoblastic --- Multiple Myeloma --- Myeloma Proteins --- Lymphatic Diseases --- Hematologic Neoplasms --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Lymphoproliferative disorders --- Reticulo-endothelial system --- Tumors
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