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Nucleic acids --- Conformation

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Proteins --- Drug development --- Drug Design --- Protein Conformation --- Crystallization --- Crystallography

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This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed.*Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Energy Metabolism --- Macromolecular Systems --- Allosteric Regulation --- Molecular Conformation --- Thermodynamics --- Macromolecules --- Bioenergetics --- Macromolécules --- Bioénergétique --- Thermodynamique --- Bioenergetics. --- Macromolecules. --- Allosteric proteins. --- Cooperative binding (Biochemistry). --- Energy Metabolism. --- Thermodynamics. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Energy metabolism. --- Metabolism. --- Nutrition. --- Macromolécules --- Bioénergétique --- Enzymology --- Allosteric Regulation. --- Molecular Conformation. --- Molecular biology --- ENERGY METABOLISM --- MOLECULAR ASSOCIATION --- PROTEINS --- THERMODYNAMICS --- CONFORMATION --- REACTIONS --- Cooperative binding (Biochemistry) --- Allosteric enzymes. --- Protein folding.

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Biophysics --- DNA --- Nonlinear mechanics --- Mechanics, Nonlinear --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Biological physics --- Conformation --- Structure --- Mechanics, Analytic --- Deoxyribose --- Nucleic acids --- Genes --- Biology --- Medical sciences --- Physics

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Takes the novel approach to cover both the sequence and structure analysis of proteins in one volume and from an algorithmic perspective. It provides a comprehensive introduction to the analysis of protein sequence and structure analysis; takes an algorithmic approach, relying on computational methods rather than theoretical; provides an integrated presentation of theory, examples, exercises and applications; and includes coverage of both protein structure, and sequence, analysis. This book is accessible enough for biologists, yet rigorous enough for computer scientists and mathematicians.

Proteins --- Bioinformatics --- Protein Conformation --- Sequence Analysis, Protein --- Algorithms --- Computational Biology --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Amino Acid Sequence Analyses --- Amino Acid Sequence Determination --- Amino Acid Sequence Determinations --- Amino Acid Sequencing --- Peptide Sequence Determination --- Protein Sequencing --- Sequence Analyses, Amino Acid --- Sequence Analysis, Amino Acid --- Sequence Analysis, Peptide --- Sequence Determination, Amino Acid --- Sequence Determinations, Amino Acid --- Amino Acid Sequence Analysis --- Peptide Sequence Analysis --- Protein Sequence Analysis --- Sequence Determination, Protein --- Acid Sequencing, Amino --- Analyses, Peptide Sequence --- Analyses, Protein Sequence --- Analysis, Peptide Sequence --- Analysis, Protein Sequence --- Peptide Sequence Analyses --- Peptide Sequence Determinations --- Protein Sequence Analyses --- Protein Sequence Determination --- Protein Sequence Determinations --- Sequence Analyses, Peptide --- Sequence Analyses, Protein --- Sequence Determination, Peptide --- Sequence Determinations, Peptide --- Sequence Determinations, Protein --- Sequencing, Amino Acid --- Sequencing, Protein --- Molecular Sequence Annotation --- Algorithm --- Structure --- methods --- Data processing --- bioinformatics --- databanken --- databases --- aminozuursequenties --- amino acid sequences --- nucleotidenvolgordes --- nucleotide sequences --- chemische structuur --- chemical structure --- studieboeken --- textbooks --- eiwitten --- proteins --- Proteomics