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Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.

Medicine. --- Proteomics. --- Biomedicine. --- Biomedicine general. --- Biomedicine, general. --- Molecular biology --- Proteins --- Health Workforce

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Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.

Brain --- Tumors in children. --- Molecular biology --- Immunohistochemistry. --- Tumors. --- Research. --- Immunohistology --- Pediatric oncology --- Medicine. --- Cancer research. --- Oncology. --- Neurobiology. --- Biomedicine. --- Cancer Research. --- Histochemistry --- Immunochemistry --- Children --- Diseases --- Oncology  . --- Neurosciences --- Tumors --- Cancer research

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About the Series: Bioelectric Engineering presents state-of-the-art discussions on modern biomedical engineering with respect to applications of electrical engineering and information technology in biomedicine. This focus affirms Springer’s commitment to publishing important reviews of the broadest interest to biomedical engineers, bioengineers, and their colleagues in affiliated disciplines. Recent volumes have covered modeling and imaging of bioelectric activity, neural engineering, biosignal processing, bionanotechnology, among other topics. Key Features of this Volume: Neural Engineering, Bioelectric Engineering Volume 2, contains reviews and discussions of contemporary and relevant topics by leading investigators in the field. It is intended to serve as a textbook at the graduate and advanced undergraduate level in a bioengineering curriculum. The topics include: – Neural Prostheses – Neural Interfacing – Neural Robotics – Functional Neural Stimulation – Neural Imaging – Neural Computation – Neural Networks – Neural System Identification and Prediction – Retinal Neuroengineering This principles and applications approach to neural engineering is essential reading for all academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals wishing to take advantage of the latest and greatest in this emerging field. About the Editor: Bin He, PhD., IEEE Fellow, is a leading figure in the field of bioelectric engineering. An internationally recognized scientist with numerous publications, Dr. He has served as the President of the International Society of Bioelectromagnetism and as an Associate or Guest Editor for nine international journals in the field of biomedical engineering. Dr. He is currently Professor of Biomedical Engineering at the University of Minnesota.

Nanostructures. --- Biomedical materials. --- Biotechnology. --- Chemical engineering --- Genetic engineering --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Nanoscience --- Physics --- Medicine. --- Biomedical engineering. --- Neurosciences. --- Radiology, Medical. --- Biomedicine general. --- Biomedical Engineering and Bioengineering. --- Biological and Medical Physics, Biophysics. --- Imaging / Radiology. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Biophysics. --- Biological physics. --- Radiology. --- Biomedicine, general. --- Health Workforce --- Radiological physics --- Radiation --- Biological physics --- Biology

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Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.

Brain. --- Brain - Diseases - Molecular aspects. --- Erythrocytes. --- Brain --- Erythrocytes --- Chorea --- Dyskinesias --- Neurologic Manifestations --- Movement Disorders --- Nervous System Diseases --- Signs and Symptoms --- Central Nervous System Diseases --- Pathological Conditions, Signs and Symptoms --- Diseases --- Neurology --- Medicine --- Health & Biological Sciences --- Molecular aspects --- Red blood cells --- Red blood corpuscles --- Red cells --- Cerebrum --- Mind --- Molecular aspects. --- Medicine. --- Human genetics. --- Neurosciences. --- Biomedicine. --- Human Genetics. --- Blood cells --- Central nervous system --- Head

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Academic Scientists at Work guides the scientist on the journey from the end of a postdoctoral career to the point of promotion to Associate Professor. The book includes valuable advice on: -Choosing and getting your ideal academic job; -Setting up and effectively managing the lab; -Obtaining funds; -Teaching and mentoring; -The promotion and tenure process. Also offered are template worksheets and point-by-point instructions on how to complete them, with downloadable blank worksheet versions contained in the accompanying CD-ROM. Included are six database program files that can be used to help the reader organize his/her laboratory specific reagents. Academic Scientists at Work is a valuable resource for the Career Scientist who demands and expects the best.

Scientists --- Research. --- Research --- Scientifiques --- Recherche --- Vocational guidance. --- Orientation professionnelle --- Education. --- Life sciences. --- Medicine. --- Research - Vocational guidance. --- Science_xStudy and teaching. --- Scientists. --- Science --- Education --- Psychology, Industrial --- Choice Behavior --- Psychology, Educational --- Psychology, Applied --- Natural Science Disciplines --- Decision Making --- Anthropology, Education, Sociology and Social Phenomena --- Thinking --- Disciplines and Occupations --- Psychological Phenomena and Processes --- Mental Processes --- Psychiatry and Psychology --- Vocational Guidance --- Career Choice --- Teaching --- Physical Sciences & Mathematics --- Sciences - General --- Vocational guidance --- Science education. --- Education, general. --- Science Education. --- Life Sciences, general. --- Biomedicine general. --- Study and teaching. --- Biomedicine, general. --- Health Workforce --- Biosciences --- Sciences, Life --- Science education --- Scientific education --- Children --- Education, Primitive --- Education of children --- Human resource development --- Instruction --- Pedagogy --- Schooling --- Students --- Youth --- Civilization --- Learning and scholarship --- Mental discipline --- Schools --- Training --- Science as a profession --- Science research --- Scientific research --- Information services --- Methodology --- Research teams