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Steven A. Rosenberg, MD In the past two decades significant progress has quality of life. The use of local radiation therapy has occurred, in the management of patients with mus- had a profound impact on the ability to achieve local loskeletal cancers, that has improved both the survival control. Cooperation between surgeons and radiation and the quality of life of afflicted patients. Changes in therapists often results in the tailoring of surgical p- the management of these patients have mirrored cedures to maximize the combined application of these trends in the entire field of oncology. two effective treatment modalities. Although impact on The most significant change has been improvement overall survival has not been demonstrated due to the in the surgical techniques for the resection of musculo- addition of radiation therapy, important advances in skeletal cancers based on a detailed understanding of improving the quality of life of patients receiving this the anatomic features of each particular tumor site, as combined-modality treatment have been evident. well as an appreciation of the natural biology that affects A third change impacting on the survival of patients the local spread of these tumors. The current volume of with musculoskeletal cancers has been the aggressive Musculoskeletal Cancer Surgery: Treatment of Sarcomas and resection of metastatic deposits.

Musculoskeletal system --- Sarcoma --- Muscles --- Soft tissue tumors --- Cancer --- Surgery. --- Orthopedics. --- Surgical oncology. --- Oncology  . --- Surgical Oncology. --- General Surgery. --- Pediatric Surgery. --- Oncology. --- Pediatric surgery. --- Tumors --- Pediatric surgery --- Surgery, Pediatric --- Children --- Surgery, Primitive --- Medicine --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Orthopaedics --- Orthopedia --- Surgery --- Diseases --- Treatment --- Excision --- Limb salvage. --- Limb-saving surgery --- Limb-sparing surgery --- Salvage of limbs --- Extremities (Anatomy) --- Therapeutics, Surgical

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The advances in our understanding of genetics has exploded since the publication of the first edition of Inherited Cancer Syndromes. We’ve moved from an incomplete understanding of the human genome to the availability of over-the-counter DNA analysis kits. There is simply too much complicated, high-level science for a busy clinician to meaningfully absorb without a filter. Inherited Cancer Syndromes is designed to bridge that gap. With this new edition, the clinical content has been expanded and clarified in order to be more tightly focused on the real-world implications of emerging therapies. The chapter authors are among the leading experts in these topics. Naturally, this book is not meant to be an exhaustive “how to” textbook or procedure-heavy monograph, but a clinically relevant overview of this dynamic and difficult aspect of cancer patient care. “ The chapters on syndromes are divided by type of cancer, and each includes discussions of risk assessment, indications for genetic testing, interpretation of test results, and integration into clinical management of risk estimates and results of genetic testing. The chapter on breast cancer also provides an insightful discussion of surrogate end-point markers. Each syndrome of susceptibility to polyposis and nonpolyposis colon cancer is described, with algorithms as to when genetic testing is indicated. Guidelines for prevention and management follow. … This book provides the knowledge base needed for most physicians to incorporate the principles of inherited susceptibility to cancer and genetic testing properly into their practices. It is highly recommended, since many physicians and health care workers have not been trained in this area, which has become an established part of clinical medicine.” Book Review, New England Journal of Medicine Volume 351:2137-2138 November 11, 2004 Number 20.

Cancer -- Genetic aspects. --- Genetic disorders. --- Medicine. --- Cancer --- Genetic disorders --- Biology --- Neoplasms --- Genetic Diseases, Inborn --- Biological Science Disciplines --- Diseases --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Neoplastic Syndromes, Hereditary --- Genetics --- Natural Science Disciplines --- Disciplines and Occupations --- Medicine --- Surgery & Anesthesiology --- Health & Biological Sciences --- Oncology --- Surgery - General and By Type --- Genetic aspects --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Hereditary Cancer Syndromes --- Hereditary Neoplastic Syndromes --- Cancer Syndromes, Hereditary --- Cancer Syndrome, Hereditary --- Hereditary Cancer Syndrome --- Hereditary Neoplastic Syndrome --- Neoplastic Syndrome, Hereditary --- Syndrome, Hereditary Cancer --- Syndrome, Hereditary Neoplastic --- Syndromes, Hereditary Cancer --- Syndromes, Hereditary Neoplastic --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Congenital diseases --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Cancer genetics --- Cancer research. --- Human genetics. --- Oncology. --- Surgery. --- Surgical oncology. --- Medicine & Public Health. --- General Surgery. --- Surgical Oncology. --- Human Genetics. --- Cancer Research. --- Oncology  . --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Heredity, Human --- Human biology --- Physical anthropology --- Excision --- Treatment --- Cancer research --- Genetic aspects.