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Carrying on the high standards of the much-acclaimed first edition, highly experienced investigators have extensively updated Signal Transduction Protocols with many of the new approaches that have been transforming the field. Included in this new edition are readily reproducible immunoassays, fluorescence-based assays, high-throughput methods, protein modification assays, lipid second messenger assays, and chromatin immunoprecipitation techniques. Wherever possible, protocols for the assay of general classes of signal transduction components have been identified so they can be adapted to the assay of any member of that class. The protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and eminently practical, Signal Transduction Protocols, 2nd ed. offers novice and experienced researchers alike an indispensable set of standardized, but readily adaptable, approaches for the assay of key signaling molecules-an invaluable tool for all laboratories newly entering the field, expanding the breadth of previous investigations, or seeking to improve an existing approach.

Cellular signal transduction --- G proteins --- Cell receptors --- GTP-Binding Proteins --- Signal Transduction --- analysis --- physiology --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane proteins --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cellular signal transduction - Laboratory manuals --- G proteins - Laboratory manuals --- Cell receptors - Laboratory manuals --- GTP-Binding Proteins - analysis - laboratory manuals --- Signal Transduction - physiology - Laboratory Manuals

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INTEGRATION OF METABOLISM, ENERGETICS, AND SIGNAL TRANSDUCTION Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease ROBERT K. OCKNER "Dr. Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration. He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena. Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease. Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but is a must read for scientists with an interest in the connection between metabolic pathways and brain function." — Dr. Bruce Miller, Professor of Neurology Clinical director of the Memory and Aging Center University of California, San Francisco "I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book." —M.A.Q. Siddiqui, Professor and Chairman of the Department of Anatomy and Cell Biology SUNY Downstate, Brooklyn, NY Robert K. Ockner, M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division of Gastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital. Cover art by Sadie McFarlane.

Cell metabolism. --- Energy metabolism. --- Cellular signal transduction. --- Fatty acids --- Pathology, Cellular. --- Metabolism. --- Neurology. --- Biochemistry. --- Applied psychology. --- Neurosciences. --- Biochemistry, general. --- Biological Psychology. --- Neurology . --- Biological psychology. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological psychology --- Biopsychology --- Biology --- Human behavior --- Psychology --- Biological psychiatry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medicine --- Neuropsychiatry --- Composition --- Diseases --- Cellular pathology --- Cytopathology --- Pathology --- Cytodiagnosis --- Acids, Fatty --- Carboxylic acids --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Metabolism --- Microbial respiration --- Cells