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Genetic engineering --- Genes --- Law and legislation --- Patents. --- Patents --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Units of heredity --- Units of inheritance --- Heredity --- Molecular genetics --- DNA --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Genetic engineering - Law and legislation - Great Britain. --- Genes - Great Britain - Patents. --- DROIT MEDICAL --- BIOETHIQUE --- EXPERIMENTATION MEDICALE --- THERAPIE GENETIQUE --- OGM

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The authors conclude that while IGM cannot be carried out safely and responsibly on humans utilizing current methods, it is important to begin public discussion now to determine whether, and if so how, to proceed.

Public Policy. --- Bioethical Issues. --- Genetic Engineering. --- Medical genetics. --- Genetic engineering --- Genetic engineering. --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Government policy --- Moral and ethical aspects. --- Genetic aspects

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The Human Genome Project, discoveries in molecular biology and new reproductive technologies have advanced our understanding of how genetic science may be used to treat persons with genetic disorders. Greater knowledge may also make possible genetic interventions to "enhance" normal human characteristics, such as height, hair or eye colour, strength, or memory, as well as the transmittal of such modifications to future generations. The prospect of inheritable genetic modifications, or IGMs, whether for therapeutic or enhancement purposes, raises complex scientific, ethical and regulatory issues. This volume presents 20 essays by physicians, scientists, philosophers, theologians, lawyers and policy analysts addressing these issues from diverse perspectives. In three sections, the authors discuss the short- and long-term scientific feasibility of IGM technology; ethical and religious issues related to safety, justice, morality, reproductive rights, and enhancement; and regulatory issues including the necessity of public input and oversight and the influence of commercialization. Their goal is to open a dialogue engaging not only scholars and scientists but also government officials and concerned citizens. The authors conclude that while IGM cannot be carried out safely and responsibly on humans utilizing current methods, it is important to begin public discussion now to determine whether, and if so how, to proceed. The prospect of inheritable genetic modifications for therapeutic or enhancement purposes raises complex scientific, ethical and regulatory issues. These 20 essays, by physicians, lawyers, theologians and others, address these issues from a variety of perspectives.

Bioethical Issues. --- Genetic Engineering. --- Genetic engineering --- Genetic engineering. --- Medical genetics. --- Public policy. --- Government policy --- Moral and ethical aspects. --- menselijk genoom --- gentherapie --- ethiek (ethische aspecten) --- godsdienst (religie, religieuze aspecten) --- génome humain --- thérapie génique --- ethique (aspects ethiques) --- religion (aspects religieux) --- Medical genetics --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Moral and ethical aspects --- Genetic aspects

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Lentivirus vector-based technologies, through in vitro and in vivo gene transfer in eukaryotic animal cells, currently offer the most promising opportunities for curing genetic disorders, as well as cancer and infectious diseases. In Lentivirus Gene Engineering Protocols, Maurizio Federico has assembled a panel of outstanding experimenters to detail all the theoretical and practical aspects of lentivirus vector-based gene transfer. The authors demonstrate lentivirus vector production with detailed methods for recovering appropriate producer cells, for producing and titrating lentivirus-containing supernatants, and for detecting transduced cells. The applications of lentivirus vector engineering to different cell types include coverage of lymphocytes, dendritic cells, hematopoietic stem and progenitor cells, mesenchymal stem cells, hippocampal neurons, cardiomyocytes, as well as airway epithelia, corneal cells, and retinal pigment. The use of non-HIV-1-based lentivirus vectors is shown to be advantageous, particularly those obtained from the genomes of HIV-2, SIV, or FIV. Also advanced are applications in which genetic material is directly inoculated with lentivirus vectors in such experimental animal models as mouse, rat, and rabbit. Comprehensive and informative, Lentivirus Gene Engineering Protocols presents a broad spectrum of the latest methods of lentivirus vector technology, offering hematologists, neurologists, geneticists, and virologists the most promising and up-to-date tools available for gene therapy in such still fatal diseases as cancer, cystic fibrosis, and AIDS.

Genetic engineering --- Lentiviruses --- Genetic vectors --- Génie génétique --- Lentivirus --- Vecteurs de clonage --- Genetic engineering. --- Lentiviruses. --- Genetic vectors. --- Electronic books. -- local. --- Genetic Structures --- Genetic Techniques --- Retroviridae --- Genetic Phenomena --- RNA Viruses --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Viruses --- Phenomena and Processes --- Vertebrate Viruses --- Organisms --- Gene Targeting --- Genetic Engineering --- Gene Transfer Techniques --- Genetic Vectors --- Biology --- Health & Biological Sciences --- Genetics --- Génie génétique --- Life sciences. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biosciences --- Sciences, Life --- Science --- Cloning vectors --- Expression vectors (Genetics) --- rDNA vectors --- Recombinant DNA vectors --- Vectors, Genetic --- Gene expression --- Molecular cloning --- Recombinant DNA --- Lentivirinae --- Retroviruses --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Cytology.