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Colorectal Neoplasms, Hereditary Nonpolyposis --- Germ-Line Mutation --- DNA-Binding Proteins --- genetics --- genetics --- genetics
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Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal its unique structural features and biochemical functions. In p53 Protocols, Sumitra and Swati Palit Deb have assembled an indispensable collection of novel techniques that have proven most useful for studying the physiological properties of p53 both in vitro and in vivo. Described by leading basic and clinical researchers who have successfully used the methods, the techniques provide proven solutions to problems in studying the purification, target identification, gene expression, quantitation, interaction, signaling, transactivation, and transrepression of p53. The methods are also useful for delineating the functions of other proteins that may act as tumor or growth suppressors. Each technique includes step-by-step instructions, troubleshooting notes, a theoretical review, and discussion of associated problems that might arise during the course of investigation. Special effort has been made to discuss problems and their solutions to help ease the learning curve when standardizing a new method. Diverse and highly practical, p53 Protocols offers both beginning and experienced researchers in cancer biology a gold-standard compendium of readily reproducible techniques for studying p53 and related proteins.
Protein p53 --- Tumor Suppressor Proteins --- Genes, p53 --- Neoplasms --- p53 protein --- p53 antioncogene --- Protéine p53 --- Gène p53 --- analysis --- therapeutic use --- physiology --- genetics --- Laboratory manuals --- Manuels de laboratoire --- Electronic books. -- local. --- p53 antioncogene -- Laboratory manuals. --- p53 protein -- Laboratory manuals. --- Tumor Suppressor Protein p53 --- Genetics --- Physiology --- Biological Science Disciplines --- Phosphoproteins --- DNA-Binding Proteins --- Biology --- Genes, Tumor Suppressor --- Nuclear Proteins --- Neoplasm Proteins --- Diseases --- Proteins --- Genes, Recessive --- Natural Science Disciplines --- Genes, Neoplasm --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Genes --- Chemicals and Drugs --- Genome Components --- Genome --- Genetic Structures --- Genetic Phenomena --- Phenomena and Processes --- Animal Biochemistry --- Cytology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Protéine p53 --- Gène p53 --- p53 gene --- p53 suppressor gene --- Antioncogenes --- Protein TP53 --- TP53 protein --- DNA-binding proteins --- Tumor suppressor proteins --- analysis. --- physiology. --- genetics. --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Cells --- Cytologists
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Nuclear Receptors are inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences.*Analysis of Nuclear Receptor Ligands*Structure/Function Analysis of Nuclear Receptors*Analysis of Nuclear Receptor Co-Factors and Chromatin Remodeling
Nuclear receptors (Biochemistry). --- Laboratory Chemicals --- Proteins --- DNA-Binding Proteins --- Investigative Techniques --- Transcription Factors --- Biochemical Phenomena --- Pharmacological Phenomena --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Amino Acids, Peptides, and Proteins --- Specialty Uses of Chemicals --- Chemical Phenomena --- Phenomena and Processes --- Chemical Actions and Uses --- Chemicals and Drugs --- Receptors, Cytoplasmic and Nuclear --- Structure-Activity Relationship --- Models, Animal --- Ligands --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- Cytoplasmic Hormone Receptors --- Cytoplasmic Receptors --- Cytosol and Nuclear Receptors --- Intracellular Membrane Receptors --- Nuclear Hormone Receptors --- Nuclear Receptors --- Receptors, Cytoplasmic --- Receptors, Cytosol and Nuclear --- Receptors, Cytosolic and Nuclear --- Receptors, Intracellular Membrane --- Receptors, Nuclear --- Receptors, Nuclear and Cytoplasmic --- Cytoplasmic and Nuclear Receptors --- Cytosolic and Nuclear Receptors --- Hormone Receptors, Cytoplasmic --- Hormone Receptors, Nuclear --- Nuclear and Cytoplasmic Receptors --- Membrane Receptors, Intracellular --- Receptors, Cytoplasmic Hormone --- Receptors, Nuclear Hormone --- Hormones --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Specialty Chemicals and Products --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Processes --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Gene Expression Regulation --- Transcription, Genetic --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- DNA Binding Protein --- DNA Single-Stranded Binding Protein --- SS DNA BP --- Single-Stranded DNA-Binding Protein --- DNA Helix Destabilizing Proteins --- Single-Stranded DNA Binding Proteins --- Binding Protein, DNA --- DNA Binding Proteins --- DNA Single Stranded Binding Protein --- DNA-Binding Protein, Single-Stranded --- Single Stranded DNA Binding Protein --- Single Stranded DNA Binding Proteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Chemicals, Laboratory --- Ligand --- Cytoplasmic Receptor --- Nuclear Hormone Receptor --- Nuclear Receptor --- Hormone Receptor, Nuclear --- Receptor, Cytoplasmic --- Receptor, Nuclear --- Receptor, Nuclear Hormone --- DNA-Binding Protein --- Protein, DNA-Binding --- Protein
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