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Pharmacy --- Statistics. --- Statistique
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Substance-Related Disorders --- Pharmacists --- Legislation, Pharmacy --- Ethics, Pharmacy
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Tantalizing new research frontiers are opening in peptide research, where the endothelins constitute an important class of signals that can be manipulated therapeutically to treat cardiovascular disease. In Peptide Research Protocols: Endothelin, a panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of peptide research by focusing on the endothelin system-from its synthesis and metabolism, to its function in health and disease. These methods use state-of-the-art molecular techniques to quantify the expression of mRNA, here using both endothelin receptors and the endothelin-converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies, and how radioligand binding techniques can provide additional information on receptor characterization. In vitro assays are presented to determine the function of peptides in isolated preparations, to characterize new receptor ligands, and to provide information on the tissue-specific processing of precursor peptides-all in the endothelin system. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function. Authoritative and timely, Peptide Research Protocols: Endothelin provides both a comprehensive introduction to endothelin biology and an up-to-date collection of proven techniques and experimental strategies for use in peptide research today.
Pharmacy. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology
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Since its first use in antibiotic research in the 1940s, High Throughput Screening (HTS) has evolved into a major enabling tool and methodology in the discovery of pharmaceutical, chemical, and agricultural compounds. In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wished had been available when they started in HTS, these seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge. By presenting accounts not only of the basic principles underlying HTS technology, but also real-use cases, High Throughput Screening constitutes a highly practical introduction to HTS, even as it also provides sufficient detail to work more productively in today's lead generation laboratories.
Pharmacy. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology
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Ethics, Pharmacy --- Ethics, Medical --- Pharmaceutical ethics
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Hospital pharmacies --- Pharmacology --- Pharmacy --- Hospital pharmacies. --- Pharmacology. --- Pharmacy. --- Pharmacy Service, Hospital. --- Hospital pharmacy departments --- Hospital pharmacy service --- Hospitals --- Pharmaceutical services --- Chemistry --- Medicine --- Drugs --- Materia medica --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Hospital Pharmaceutic Service --- Hospital Pharmaceutical Service --- Hospital Pharmacy Services --- Pharmaceutic Service, Hospital --- Pharmaceutical Service, Hospital --- Service, Clinical Pharmacy --- Service, Hospital Pharmaceutic --- Service, Hospital Pharmaceutical --- Service, Hospital Pharmacy --- Clinical Pharmacy Service --- Hospital Pharmacy Service --- Pharmacy Service, Clinical --- Clinical Pharmacy Services --- Hospital Pharmaceutic Services --- Hospital Pharmaceutical Services --- Pharmaceutic Services, Hospital --- Pharmaceutical Services, Hospital --- Pharmacy Services, Clinical --- Pharmacy Services, Hospital --- Services, Clinical Pharmacy --- Services, Hospital Pharmaceutic --- Services, Hospital Pharmaceutical --- Services, Hospital Pharmacy --- Pharmacologies --- Pharmaceutical Preparations --- Pharmacies --- Pharmacy departments --- Pharmacy service --- Physiological effect --- pharmacology --- Australian
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