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Liquid crystals

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Liquid crystals --- Cristaux liquides

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The cyclophosphamide is al molecule used in the treatment of many cancers, but is has also immunosuppressant properties and it is an alkylated agent.
It’s metabolised through the liver by the cytochrome P450 2B6. The active metabolite is the phosphoramide mustard. The acrolein is the toxic metabolite and may be responsible for the hemorrhagic cystitis.
In absence of strict precautions, handling of such products by hospital staff may be dangerous for their health. That’s the reason why it’s so important to be able to quantify cyclophosphamide concentration in the urines of those people.
The determination of this substance is done by LC MS/MS. The sensitivity of the assay is 0.05 ng/ml (LOD of 0.05 ng/ml and a LOQ of 0.1 ng/ml)
After 3.50 min, the sample is analysed and the result is given in ng/ml.
Once the determination of cyclophosphamide has been validated, we were able to use the assay in urines from the workers of the pharmacy of St-Luc hospital.
We have also compared our results with those obtained from the reference laboratory (Holland), and we have assessed the preanalytical conditions.
Most of the results were negative (< 0.05 ng/ml) suggesting that the air extraction system and protective measures are efficious La cytophosphamide est une molécule utilisée dans le traitement de nombreux cancers mais elle a également des propriétés immunosuppressives et c’est un agent alkylant.
Elle est métabolisée au niveau du foie par le cytochrome P450 2B6. Le métabolite actif est la moutarde phosphoramide. L’acroléine est un métabolite toxique qui peut être responsable de l’apparition d’une cystite hémorragique.
Une manipulation imprudente, par le personnel hospitalier, de tels produits peut représenter un risque pour leur santé. C’est pourquoi, il est important de pouvoir déterminer avec précision la présence ou non de cyclophosphamide dans les urines de ces personnes.
Le dosage de la cyclophosphamide se fait par LC MS/MS. La sensibilité de cette méthode est de 0.05 ng/ml (LOD de 0.05 ng/ml et une LOQ de 0.1 ng/ml).
L’échantillon est analysé en 3.50 min et le résultat est directement donné en ng/ml. Une fois le dosage de la cyclophosphamide validé, nous avons pu réaliser des dosages sur des urines provenant du personnel de la pharmacie des cliniques universitaires St-Luc.
Nous avons également comparé nos résultats avec ceux du centre international de référence (Hollande) ; ainsi que contrôlé les conditions préanalytiques. La plupart de ces dosages étaient négatifs (<0.05 ng/ml-, ce qui nous autorise à penser que les systèmes d’aération ainsi que les mesures de protection sont efficaces.

Cyclophosphamide --- Urine --- Chromatography, Liquid --- Chromatography, High Pressure Liquid

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The main topics discussed in this book are the formation of the macromolecular condensed state from isolated long chain macromolecules in dilute solution, the salient physical behavior of the polymeric amorphous state, the liquid crystalline state of rigid chain polymers, the crystallization process and the single chain condensed state, all based on experimental results. The role of intersegmental cohesion and the difference between the single chain condensed state and the interpenetrated multichain condensed state are emphasized. In addition, the book introduces and discusses some new physica

Polymer liquid crystals. --- Crystalline polymers. --- Crystal polymers --- Crystallographically ordered polymers --- Polymer crystals --- Crystals --- Polymers --- Crystals, Polymer liquid --- Liquid crystal polymers --- Liquid crystalline polymers --- Liquid crystals, Polymer --- Polymeric liquid crystals --- Liquid crystals

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Liquid crystals --- Metallomesogens --- Polymer liquid crystals --- Cristaux liquides --- Polymères cristaux liquides --- Polymères cristaux liquides