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Descriptive organic chemistry --- Technology, Pharmaceutical --- Combinatorial Chemistry Techniques --- Gene Library --- Solid-phase synthesis --- Combinatorial chemistry --- 541.5 --- 615.015.2 --- #WSCH:LOSA --- Organic compounds --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Pharmaceutical chemistry --- Biochips --- Valencies. Bonds. Affinity --- Combined effects. Action of combination of drugs --- Synthesis --- Combinatorial chemistry. --- Solid-phase synthesis. --- 615.015.2 Combined effects. Action of combination of drugs --- 541.5 Valencies. Bonds. Affinity

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In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.

Drugs --- High throughput screening (Drug development) --- Ligand binding (Biochemistry) --- Design --- Computer simulation. --- Pharmacy. --- Chemistry. --- Computer Applications in Chemistry. --- Chemoinformatics. --- Chemical informatics --- Chemiinformatics --- Chemoinformatics --- Chemistry informatics --- Chemistry --- Information science --- Computational chemistry --- Medicine --- Materia medica --- Pharmacology --- Data processing --- High throughput testing (Drug development) --- HRS (Drug development) --- Drug development --- Pharmaceutical chemistry --- Binding, Ligand (Biochemistry) --- Biochemistry --- Dye-ligand affinity chromatography --- Radioligand assay --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Pharmacy

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Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Médicament --- drugs --- Métabolite --- Metabolites --- Biosynthèse --- Biosynthesis --- Propriété pharmacologique --- medicinal properties --- Technique analytique --- Analytical methods --- Immunologie --- Immunology --- Pharmacognosy. --- Biological Factors. --- Plants, Medicinal. --- Healing Plants --- Medicinal Plants --- Pharmaceutical Plants --- Herbs, Medicinal --- Medicinal Herbs --- Healing Plant --- Herb, Medicinal --- Medicinal Herb --- Medicinal Plant --- Pharmaceutical Plant --- Plant, Healing --- Plant, Medicinal --- Plant, Pharmaceutical --- Plants, Healing --- Plants, Pharmaceutical --- Pharmaceutical Preparations --- Phytotherapy --- Medicine, Traditional --- Pharmacognosy --- Ethnopharmacology --- Herbal Medicine --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Biological Products --- Pharmacognosies --- Plants --- Plants, Medicinal --- Medicine, Mongolian Traditional --- Conferences - Meetings --- Combinatorial chemistry --- Drugs --- Biological Factors --- Design --- Pharmacognostics --- Materia medica --- Pharmacy --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Organic compounds --- Pharmaceutical chemistry --- Biochips --- Synthesis --- Biologic Agent --- Biological Agent --- Agent, Biologic --- Agent, Biological --- Pharmacology. --- Biotechnology. --- Biochemistry. --- Organic chemistry. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Organic Chemistry. --- Organic chemistry --- Chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Chemical engineering --- Genetic engineering --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Composition --- Physiological effect --- Medicaments --- Produits naturels