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This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

Biosynthesis. --- Polyketides. --- Alkaloids. --- Chemistry. --- Biochemical engineering. --- Organic chemistry. --- Biochemistry. --- Biochemical Engineering. --- Organic Chemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Composition

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Chemistry --- Biotechnology --- Chemical engineering --- Microbiology --- Biotechnologie --- Chemistry. --- Biotechnology. --- Chemical engineering. --- Microbiology. --- Industrial Chemistry/Chemical Engineering. --- Biological Science Disciplines --- Technology --- Natural Science Disciplines --- Technology, Industry, and Agriculture --- Disciplines and Occupations --- Technology, Industry, Agriculture --- History. --- History --- Microbial biology --- Biology --- Microorganisms --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Genetic engineering --- Biochemical engineering. --- Biochemistry. --- Biochemical Engineering. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Composition --- History (not cas)