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1. 1 Typical Problems of Data Analysis Every branch of experimental science, after passing through an early stage of qualitative description, concerns itself with quantitative studies of the phe­ nomena of interest, i. e. , measurements. In addition to designing and carrying out the experiment, an importal1t task is the accurate evaluation and complete exploitation of the data obtained. Let us list a few typical problems. 1. A study is made of the weight of laboratory animals under the influence of various drugs. After the application of drug A to 25 animals, an average increase of 5 % is observed. Drug B, used on 10 animals, yields a 3 % increase. Is drug A more effective? The averages 5 % and 3 % give practically no answer to this question, since the lower value may have been caused by a single animal that lost weight for some unrelated reason. One must therefore study the distribution of individual weights and their spread around the average value. Moreover, one has to decide whether the number of test animals used will enable one to differentiate with a certain accuracy between the effects of the two drugs. 2. In experiments on crystal growth it is essential to maintain exactly the ratios of the different components. From a total of 500 crystals, a sample of 20 is selected and analyzed.

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Our initial motivation for writing this book was the observation from various students that the subject of design and analysis of experiments can seem like “a bunch of miscellaneous topics. ”Webelievethattheidenti?cationoftheobjectivesoftheexperimentandthepractical considerations governing the design form the heart of the subject matter and serve as the link between the various analytical techniques. We also believe that learning about design and analysis of experiments is best achieved by the planning, running, and analyzing of a simple experiment. With these considerations in mind, we have included throughout the book the details of the planning stage of several experiments that were run in the course of teaching our classes. The experiments were run by students in statistics and the applied sciences and are suf?ciently simple that it is possible to discuss the planning of the entire experiment in a few pages, and the procedures can be reproduced by readers of the book. In each of these experiments, we had access to the investigators’ actual report, including the dif?culties they came across and how they decided on the treatment factors, the needed number of observations, and the layout of the design. In the later chapters, we have included details of a number of published experiments. The outlines of many other student and published experiments appear as exercises at the ends of the chapters. Complementing the practical aspects of the design are the statistical aspects of the anal ysis. We have developed the theory of estimable functions and analysis of variance with somecare,butatalowmathematicallevel.

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