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In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of otherwise labile peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed. Peptidomimetics Protocols is the first book devoted to the practical synthetic preparation of peptide mimetics. Written by both academic and industrial synthetic organic and medicinal chemists, this book provides highly practical synthetic procedures for the generation of key peptide mimetics, and so immediately becomes a must-have desk reference and guide for all medicinal and pharmaceutical chemists engaged in the discovery and development of pharmaceuticals today.

Biochemistry. --- Medicinal Chemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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In Carbohydrate Biotechnology Protocols, Christopher Bucke has brought together a compilation of modern hands-on methods for the effective use of microbes and enzymes to produce and modify carbohydrates of potential and actual commercial value. These powerful methods enable both the expert and the beginner to generate polysaccharides, oligosaccharides, and carbohydrate-based surfactants by fermentation using enzymes. Additional techniques make it possible to produce derivatives of sugars, other oligosaccharides, and sugar derivatives using enzyme technology. Carbohydrate Biotechnology Protocols offers synthetic chemists, biochemists, fermentation biotechnologists, and applied enzymologists cutting-edge techniques-many of them hitherto unavailable in print-that are cleaner and often less costly than available chemical alternatives. Timely and readily reproducible, these state-of-the-art protocols allow the user to produce and.

Carbohydrates --- Biotechnology. --- Biotechnology --- Chemical engineering --- Genetic engineering --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinoline alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinoline alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the va

Alkaloids. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Alcaloids --- Microbial metabolites --- Organonitrogen compounds --- Plant metabolites --- Composition

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General biochemistry --- biochemie --- celmetabolisme --- fotosynthese --- energie --- enzyme --- koolhydraat --- lipide --- metabolisme --- eiwitsynthese --- genetische informatie --- Contains audio-visual material --- Biochemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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The past few years have seen rapid progress in apoptosis research. This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis, with particular emphasis to the role of apoptosis in normal biological processes and the mechanisms involved. The articles published in this volume are written by leading experts in the field and should be a vital resource for researchers in biomedicine.

Histology. Cytology --- Apoptosis --- Cell biology. --- Biochemistry. --- Cancer research. --- Cell Biology. --- Biochemistry, general. --- Cancer Research. --- Cancer research --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Composition --- Apoptosis. --- Cell death