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Retinoids : the biochemichal and molecular basis of vitamin A and retinoid action
Authors: ---
ISBN: 3540658920 3642636144 3642584837 Year: 1999 Volume: 139 Publisher: Berlin ; Heidelberg ; New York Springer Verlag

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Abstract

In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re­ cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper­ imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.

Tamoxifen and breast cancer
Authors: ---
ISBN: 0585349444 9780585349442 0300079516 Year: 1999 Publisher: New Haven, Conn : Yale University Press,

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Keywords

Tamoxifen. --- Breast --- Breast Neoplasms --- Tamoxifen --- Stilbenes --- Breast Diseases --- Neoplasms by Site --- Skin Diseases --- Neoplasms --- Benzylidene Compounds --- Benzene Derivatives --- Diseases --- Skin and Connective Tissue Diseases --- Hydrocarbons, Aromatic --- Hydrocarbons, Cyclic --- Hydrocarbons --- Organic Chemicals --- Chemicals and Drugs --- Oncology --- Medicine --- Health & Biological Sciences --- Hydrocarbon --- Saturated Hydrocarbons --- Unsaturated Hydrocarbons --- Hydrocarbons, Saturated --- Hydrocarbons, Unsaturated --- Cyclic Hydrocarbons --- Hydrocarbons, Polycyclic --- Polycyclic Hydrocarbons --- Aromatic Hydrocarbon --- Aromatic Hydrocarbons --- Hydrocarbon, Aromatic --- Derivatives, Benzene --- Benzene --- Benzylidene Compound --- Benzylidene Derivative --- Benzylidene Derivatives --- Phenylmethylene Derivative --- Phenylmethylene Derivatives --- Compound, Benzylidene --- Compounds, Benzylidene --- Derivative, Benzylidene --- Derivative, Phenylmethylene --- Derivatives, Benzylidene --- Derivatives, Phenylmethylene --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Dermatosis --- Dermatoses --- Skin and Subcutaneous Tissue Disorders --- Skin Disease --- Dermatology --- Neoplasms by Sites --- Site, Neoplasm --- Sites, Neoplasm --- Neoplasm Site --- Neoplasm Sites --- Endocrine Breast Diseases --- Breast Disease --- Breast Disease, Endocrine --- Breast Diseases, Endocrine --- Disease, Breast --- Disease, Endocrine Breast --- Diseases, Breast --- Diseases, Endocrine Breast --- Endocrine Breast Disease --- Stilbene --- Stilbene Derivative --- Stilbene Derivatives --- Stilbenoid --- Stilbenoids --- Derivative, Stilbene --- Derivatives, Stilbene --- Allylbenzene Derivatives --- Breast Carcinoma --- Cancer of the Breast --- Human Mammary Carcinoma --- Malignant Neoplasm of Breast --- Malignant Tumor of Breast --- Mammary Cancer --- Mammary Carcinoma, Human --- Mammary Neoplasm, Human --- Mammary Neoplasms, Human --- Neoplasms, Breast --- Tumors, Breast --- Breast Cancer --- Breast Tumors --- Cancer of Breast --- Breast Carcinomas --- Breast Malignant Neoplasm --- Breast Malignant Neoplasms --- Breast Malignant Tumor --- Breast Malignant Tumors --- Breast Neoplasm --- Breast Tumor --- Cancer, Breast --- Cancer, Mammary --- Cancers, Mammary --- Carcinoma, Breast --- Carcinoma, Human Mammary --- Carcinomas, Breast --- Carcinomas, Human Mammary --- Human Mammary Carcinomas --- Human Mammary Neoplasm --- Human Mammary Neoplasms --- Mammary Cancers --- Mammary Carcinomas, Human --- Neoplasm, Breast --- Neoplasm, Human Mammary --- Neoplasms, Human Mammary --- Tumor, Breast --- Breast Cancer Lymphedema --- ICI-46,474 --- ICI-46474 --- ICI-47699 --- Nolvadex --- Novaldex --- Soltamox --- Tamoxifen Citrate --- Tomaxithen --- Zitazonium --- Citrate, Tamoxifen --- ICI 46,474 --- ICI 46474 --- ICI 47699 --- ICI46,474 --- ICI46474 --- ICI47699 --- Antineoplastic agents --- Ethylamines --- Selective estrogen receptor modulators --- Organic Chemical --- Chemical, Organic --- Chemicals, Organic --- Chemoprevention. --- drug therapy. --- therapeutic use. --- prevention & control. --- analogs & derivatives --- Breast Neoplasms. --- Stilbenes. --- Breast Diseases. --- Neoplasms by Site. --- Skin Diseases. --- Neoplasms. --- Benzylidene Compounds. --- Benzene Derivatives. --- Disease. --- Skin and Connective Tissue Diseases. --- Hydrocarbons, Aromatic. --- Hydrocarbons, Cyclic. --- Hydrocarbons. --- Organic Chemicals.

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