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On day 2 after delivery, dam of the DBA/1 mouse inbred strain (n=20/group) with their litter were allocated to one of the following groups: NH21, nonhandling, housed 1 litter/cage, weaned on postnatal day (PND) 21; H21, handling, housed 1 litter/cage, weaned on PND 21; NH30, nonhandling, group-housed (5 litters/cage), weaned on PND 30; H30, handling, group-housed (5 litters/cage), weaned on PND 30. Two male pups of each litter were color marked on PND 2. From PND 8-21 they were removed from their cage, gently held in the experimenter's hand for 5 min/day. The two marked males of each litter were housed together after weaning, and tested in the open-field on PNDs 51-53, and one of each of these siblings was tested for hot-plate latencies on PND 54. Being raised in group-housing and weaned on PND 30 resulted in offspring exhibiting shorter latencies to initiate behavior and higher percentages of centerfield entries in the open field, hot-plate latencies, however, remained unaffected. Preweaning handling increased hot-plate latencies and the number of grooming episodes in the open field, and it decreased defecation, percent centerfield entries and open-field activity in general. It is concluded that the two forms of early experience have different effects on neurobehavioral endpoints 8 weeks after birth

Activity. --- Adult-rats. --- Behavior. --- Birth. --- Brain. --- Cage. --- Color. --- Early experience,postnatal handling communal rearing,open field,hot plate,nociception,mice. --- Early experience. --- Emotionality. --- Environmental enrichment. --- Experience. --- Exposure. --- Field. --- Grooming. --- Group housing. --- Group. --- Handling. --- Hippocampus. --- Increases. --- Locomotor-activity. --- Male. --- Males. --- Mice. --- Morphine. --- Mouse. --- Novelty. --- Open field. --- Open-field activity. --- Open-field behavior. --- Open-field. --- Pups. --- Rearing. --- Weaning.