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Energy transfer --- Cellular signal transduction

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Lipids --- Lipids. --- Cell Communication. --- Signal Transduction. --- Metabolism --- Metabolism. --- metabolism. --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Metabolism, Lipid --- Lipid metabolism --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Lipides --- Lipins --- Lipoids --- metabolism --- Cell Communication --- Signal Transduction --- Lipid Metabolism. --- Biomolecules --- Steroids --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Cell Signaling

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R. A. J. Challiss assembles in Receptor Signal Transduction Protocols an outstanding collection of state-of-the-art methods from leading experts for interrogating ligand-receptor and receptor-effector interactions. These powerful methods emphasize the regulation of G-protein-coupled receptors and focus on receptor characterization, methods for investigating how receptors couple to G-proteins, and approaches to studying how receptor expression and function is regulated. Designed to be easily reproducible, the protocols offered include chimeric receptor construction, antibody generation, transient and stable transfection methods, in situ hybridization, as well as immunocytochemistry, functional assays of G-protein function, antisense methods for defining receptor-effector coupling pathways, and many more. Receptor Signal Transduction Protocols blends authoritative descriptions and applications of well-established methodologies with many novel techniques at the cutting edge of signal transduction research. The coverage cuts across disciplines and allows those already well-versed in one area to expand their repertoire of potent methods and broaden their research horizons. Every researcher interested in signal transduction today will find this richly practical guide indispensable.

Cellular signal transduction --- Cell receptors --- Research --- Methodology --- Physiology --- Signal Transduction --- Biochemical Processes --- Cell Physiological Processes --- Biological Science Disciplines --- Cell Physiological Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Chemical Processes --- Disciplines and Occupations --- Chemical Phenomena --- Phenomena and Processes --- Cytology --- Biology --- Health & Biological Sciences --- Methodology. --- physiology. --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cellular signal transduction - Research - Methodology --- Cell receptors - Research - Methodology

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Human biochemistry --- Celinteractie --- Cell communication --- Cell interaction --- Cell-cell interaction --- Cellular communication (Biology) --- Cellular information transduction --- Cellular interaction --- Cellular signal transduction --- Cellules--Interaction --- Celsignaal-transductie --- Information transduction [Cellular ] --- Interactie [Cel] --- Intercellular communication --- Intéraction cellulaire --- Signal transduction [Cellular ] --- Transduction du signal cellulaire

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Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

AGECP --- Acetyl glyceryl ether phosphorylcholine --- Affections plaquettaires --- Affections thrombocytaires --- Bloedplaatjes --- Bloedplaatjes--Activeringsfactor --- Bloedplaatjes--Stoornissen --- Blood platelet disorders --- Blood platelets --- Cellular information transduction --- Cellular signal transduction --- Celsignaal-transductie --- Facteur plaquettaire d'activation --- Factor [Plaatjes] activering --- Information transduction [Cellular ] --- PAF-acether --- Plaatjes [Bloed] --- Plaatjesfactor activatie --- Plaquettes sanguines --- Plaquettes sanguines--Troubles --- Platelet activating factor --- Platelets --- Signal transduction [Cellular ] --- Stoornissen van de bloedplaatjes --- Thrombocytes --- Thrombocytopathie --- Thrombocytopathy --- Thrombopathie --- Transduction du signal cellulaire --- Trombocyten --- Troubles des plaquettes sanguines --- Blood platelet disorders. --- Blood platelets. --- Cellular signal transduction. --- Platelet activating factor. --- Blood Platelets. --- Receptors. --- Receptors --- Pharmacology. --- Biochemistry. --- Human physiology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Composition --- Physiological effect --- Blood --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Choline --- Ether lipids --- Inflammation --- Phospholipids --- Blood platelet receptors --- Platelet membrane receptors --- Platelet receptors --- Cell receptors --- Blood cells --- Megakaryocytes --- Diseases --- Mediators --- Activation