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Cellular telephone is an example of a new product that has significantly affected how Americans live. Since their introduction in 1983, cellular telephone adoption has grown at 25-35% per year such that at year end 1996 about 42 million cellular telephones are in use in the U.S. However, cellular telephone has not been included in the construction of the CPI, and the CPI will not include cellular telephone until 1998 or 1999. This neglect of new goods leads to an upward bias in the CPI. The analysis of the paper demonstrates that the gains in consumer welfare from a new product such as cellular telephone can be substantial. The paper also gives an approximation result which the BLS could use to calculate gains in consumer welfare from new products for use in the CPI. The BLS telecommunications CPI estimates that since 1988, telecommunications prices have increased by 8.5% or an increase of 1.02% per year. This estimate ignores cellular service. A corrected telecommunication services COLI that includes cellular service decreased from 1.0 in 1988 to 0.903 in 1996 for a decrease of 1.28% per year. Thus, the bias in the BLS telecommunications services CPI equals approximately 2.3 percentage points per year. The neglect of new products in the CPI can lead to significant biases.
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Plant cells and tissues --- Cellular signal transduction --- Plant molecular biology
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Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.
Human biochemistry --- Sphingolipids --- Cellular signal transduction --- Physiological effect --- Metabolism --- Cell biology. --- Biochemistry. --- Cell Biology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Composition --- Sphingolipids - Physiological effect --- Sphingolipids - Metabolism
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It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questi
Cell membranes. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces
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R. A. J. Challiss assembles in Receptor Signal Transduction Protocols an outstanding collection of state-of-the-art methods from leading experts for interrogating ligand-receptor and receptor-effector interactions. These powerful methods emphasize the regulation of G-protein-coupled receptors and focus on receptor characterization, methods for investigating how receptors couple to G-proteins, and approaches to studying how receptor expression and function is regulated. Designed to be easily reproducible, the protocols offered include chimeric receptor construction, antibody generation, transient and stable transfection methods, in situ hybridization, as well as immunocytochemistry, functional assays of G-protein function, antisense methods for defining receptor-effector coupling pathways, and many more. Receptor Signal Transduction Protocols blends authoritative descriptions and applications of well-established methodologies with many novel techniques at the cutting edge of signal transduction research. The coverage cuts across disciplines and allows those already well-versed in one area to expand their repertoire of potent methods and broaden their research horizons. Every researcher interested in signal transduction today will find this richly practical guide indispensable.
Cellular signal transduction --- Cell receptors --- Research --- Methodology --- Physiology --- Signal Transduction --- Biochemical Processes --- Cell Physiological Processes --- Biological Science Disciplines --- Cell Physiological Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Chemical Processes --- Disciplines and Occupations --- Chemical Phenomena --- Phenomena and Processes --- Cytology --- Biology --- Health & Biological Sciences --- Methodology. --- physiology. --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cellular signal transduction - Research - Methodology --- Cell receptors - Research - Methodology
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Biomembranes --- Cellular signal transduction --- Congresses --- Biological transport --- Cell biology. --- Biochemistry. --- Molecular biology. --- Cell Biology. --- Biochemistry, general. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Composition
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Human biochemistry --- Celinteractie --- Cell communication --- Cell interaction --- Cell-cell interaction --- Cellular communication (Biology) --- Cellular information transduction --- Cellular interaction --- Cellular signal transduction --- Cellules--Interaction --- Celsignaal-transductie --- Information transduction [Cellular ] --- Interactie [Cel] --- Intercellular communication --- Intéraction cellulaire --- Signal transduction [Cellular ] --- Transduction du signal cellulaire
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This study unites a selection of the most fundamental and commonly used techiques and protocols for purifying and assaying inositides and related compounds. It also features a catalogue of non-commercial sources of synthetic inositide analogues.
Inositol phosphates. --- Inositol. --- Phospholipids. --- Phospholipases. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Esterases --- Phosphatides --- Membrane lipids --- Phosphates --- Cyclohexanehexol --- Mesoinositol --- Myoinositol --- Alcohols --- Phosphoinositides --- Sugars --- Vitamin B complex --- Hexose phosphates --- Human biochemistry --- Inositol Phosphates. --- Signal Transduction. --- Inositol phosphates --- Metabolism.
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Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.
AGECP --- Acetyl glyceryl ether phosphorylcholine --- Affections plaquettaires --- Affections thrombocytaires --- Bloedplaatjes --- Bloedplaatjes--Activeringsfactor --- Bloedplaatjes--Stoornissen --- Blood platelet disorders --- Blood platelets --- Cellular information transduction --- Cellular signal transduction --- Celsignaal-transductie --- Facteur plaquettaire d'activation --- Factor [Plaatjes] activering --- Information transduction [Cellular ] --- PAF-acether --- Plaatjes [Bloed] --- Plaatjesfactor activatie --- Plaquettes sanguines --- Plaquettes sanguines--Troubles --- Platelet activating factor --- Platelets --- Signal transduction [Cellular ] --- Stoornissen van de bloedplaatjes --- Thrombocytes --- Thrombocytopathie --- Thrombocytopathy --- Thrombopathie --- Transduction du signal cellulaire --- Trombocyten --- Troubles des plaquettes sanguines --- Blood platelet disorders. --- Blood platelets. --- Cellular signal transduction. --- Platelet activating factor. --- Blood Platelets. --- Receptors. --- Receptors --- Pharmacology. --- Biochemistry. --- Human physiology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Composition --- Physiological effect --- Blood --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Choline --- Ether lipids --- Inflammation --- Phospholipids --- Blood platelet receptors --- Platelet membrane receptors --- Platelet receptors --- Cell receptors --- Blood cells --- Megakaryocytes --- Diseases --- Mediators --- Activation
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