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The very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor tant chronic disorders of the nervous system such as torula and tuberculosis men ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated.
Bovine spongiform encephalopathy --- Social aspects. --- BSE (Disease) --- Mad cow disease --- Spongiform encephalopathy, Bovine --- Cattle --- Prion diseases in animals --- Creutzfeldt-Jakob disease --- Virus diseases
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SOMMAIRE.- Introduction.- Les encéphalopathies spongiformes transmissibles animales.- La tremblante naturelle du mouton (ou scrapie).- L'encéphalopathie spongiforme bovine ou Maladie des vaches folles.- Les autres encéphalopathies spongiformes animales.- Les encéphalopathies spongiformes transmissibles humaines.- Le Kuru.- La maladie de Creutzfeldt-Jacob (MCJ).- Le syndrome de Gerstmann-Sträussler-Scheinker (SGSS).- L'insomnie fatale familiale (IFF).- La paraparésie spastique (PS).- Le prion.- Historique.- Les aspects génétiques.- Les aspects biochimiques.- Les fonctions biologiques de la prion-protéine.- La diversité des prions : les diverses "souches".- Essai de synthèse : les théories du prion.- Les risques de transmission accidentelles des maladies à prion.- Précautions à prendre et recommandations.- Les essais thérapeutiques.- Conclusion.
Semiology. Diagnosis. Symptomatology --- Animaux [Maladies à prions chez les ] --- BSE (Disease) --- BSE (Maladie) --- BSE (Ziekte) --- Besmettelijke ziekten --- Besmettelijke ziekten bij dieren --- Bovine spongiform encephalopathy --- CJD (Disease) --- Communicable diseases --- Communicable diseases between animals and man --- Communicable diseases in animals --- Contagion and contagious diseases --- Contagious diseases --- Creutzfeldt-Jakob [Ziekte van ] --- Creutzfeldt-Jakob disease --- Creutzfeldt-Jakob syndrome --- Dieren [Prionziekten bij de ] --- Dierenepidemieen --- Encepholopathies [Spongiform ] --- Encéphalopathie spongiforme --- Encéphalopathie spongiforme bovine --- Epidemieen bij dieren --- Epidemies chez les animaux --- Epizootic diseases --- Epizootieen --- Epizooties --- Gekkekoeienziekte --- Heidenhain syndrome --- Infectious diseases --- Infectious protein particles --- Jakob's disease --- Jakob-Creutzfeldt disease --- Jakob-Creutzfeldt syndrome --- Jakob-Creutzfeldt-ziekte --- Kourou --- Kuru --- Maladie de Creutzfeldt-Jakob --- Maladie de la mort souriante --- Maladie de la vache folle --- Maladie des vaches folles --- Maladies contagieuses --- Maladies contagieuses chez les animaux --- Maladies contagieuses entre les animaux et l'homme --- Maladies microbiennes des animaux --- Maladies à prions --- Maladies à prions chez les animaux --- Microbial diseases in animals --- Microbial diseases in man --- Microbiele ziekten van de dieren --- Overdraagbare ziekten tussen dier en mens --- Prion diseases --- Prion diseases in animals --- Prion infections --- Prions --- Prions [Maladies à ] --- Prionziekten --- Prionziekten bij de dieren --- Protein particles [Infectious ] --- Spastic pseudosclerosis --- Spongiform encephalopathies --- Spongiform encephalopathy --- Spongiform encephalopathy [Bovine ] --- Spongiforme encefalopathie --- Sub-acute spongiform encephalopathy --- Subacute spongoform encephalopathy --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Vache folle [Maladie de la ] --- Vaches folles [Maladies des ] --- Ziekten [Besmettelijke ] --- Ziekten [Prion] --- Zoonoses --- Zoonotic diseases --- Zoönosen --- Zymotic diseases --- Prion diseases. --- Creutzfeldt-Jakob disease. --- Prion Diseases. --- Creutzfeldt-Jakob Syndrome. --- Encephalopathies, Spongiform --- Subacute spongiform encephalopathy --- Slow virus diseases --- Central nervous system --- Presenile dementia --- Diseases --- Creutzfeldt-Jakob Syndrome --- Encephalopathy, Bovine Spongiform --- Encephalopathy, Bovine Spongiform.
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