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Dissertation
Myocardial protection by allopurinol against ischemia-reperfusion injury : a clinical and experimental study
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ISBN: 9039306192 Year: 1995 Publisher: Utrecht Universiteit Utrecht

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Dissertation
Small bowel preservation : a morphological and functional study
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ISBN: 9039309604 Year: 1995 Publisher: Utrecht Universiteit Utrecht

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Book
Acute renal failure in the critically ill
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ISBN: 3540584013 9783540584018 Year: 1995 Publisher: Berlin: Springer,

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Periodical

Dissertation
Biological effects in human erythrocytes in vitro exposed to senobiotics : influences by metabolizing systems from rat liver.
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ISBN: 9052781753 Year: 1995 Publisher: Maastricht Universitaire pers

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Periodical
European journal of orthopaedic surgery & traumatology.

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Publishes articles in orthopaedic and trauma surgery.


Periodical
IP online : injury prevention.
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ISSN: 14755785 13538047 Year: 1995 Publisher: Montreal PQ, Canada : McGill Univ., Montreal Children's Hospital,

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Article
Chronic Intraventricular Norepinephrine and Delayed Neuronal Death in the Hippocampus.
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Year: 1995

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The present studies evaluated the effect of chronic intraventricular microinfusion of norepinephrine (NE) to examine if higher levels of intracerebral NE could protect against the development of delayed neuronal death (DND) in the hippocampus of a transient forebrain ischaemia model. Small cannulas connected to osmotic minipumps were stereotactically placed in the lateral ventricle, and NE (40 mu M) was pumped at the rate of 0.5 mu l/hour for periods of up to 14 days. Brain tissue was then analysed for the total NE content at 2.5 mm intervals from the cannula tip, using high pressure liquid chromatography, The result of these preliminary studies showed a 5 to 40-fold increase in the NE levels in the specimens on the infusion side and a 2 to 3-fold increase on the non-infusion side. The number of surviving pyramidal neurones in the hippocampal CA1 region were then compared between the ipsilateral and contralateral hemispheres of the brains obtained from experimental and control animals. Significant suppression of neuronal death was demonstrated in the presence of increased levels of exogenous NE on the infusion side. These studies suggest that intraventricular administration of NE is feasible and that the resulting higher levels of NE may attenuate the phenomenon of DND in the hippocampus, possibly by a direct protective action upon the neurones

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