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Natural products --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Products, Natural --- Raw materials --- Analysis. --- Composition

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The editors invited selected authors who had participated in or observed developments in biochemistry and molecular biology, particularly in the second half of this century, to record their personal recollections of the times and circumstances in which they worked. Having been given free reign, both content and style of the contruibutions reflect the flavour of the personality of the author. The book reflects the explosive development of biochemistry and molecular biology and related sciences that had led to the almost unique situation of these fields coming of age at a time when their found

Biochemists --- Biochemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Biological chemists --- Biologists --- Chemists --- Composition --- Biochemists - - Biography --- Biochemistry - - History --- -Biochemistry --- -Biochemists --- History --- Biochemistry. --- History. --- -Biochemistry.

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Biochemistry --- Chemistry, Physical and theoretical --- Biochimie --- Chimie physique et théorique --- 541.1 --- #WSCH:MODS --- Fysische chemie --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- 541.1 Physical chemistry --- Chimie physique et théorique --- Chemistry, Physical and theoretical.

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The intent of this work is to bring together in a single volume the techniques that are most widely used in the study of protein stability and protein folding. Over the last decade our understanding of how p- teins fold and what makes the folded conformation stable has advanced rapidly. The development of recombinant DNA techniques has made possible the production of large quantities of virtually any protein, as well as the production of proteins with altered amino acid sequence. Improvements in instrumentation, and the development and refinement of new techniques for studying these recombinant proteins, has been central to the progress made in this field. To give the reader adequate background information about the s- ject, the first two chapters of this book review two different, yet related, aspects of protein stability. The first chapter presents a review of our current understanding of the forces involved in determining the conf- mational stability of proteins as well as their three-dimensional folds. The second chapter deals with the chemical stability of proteins and the pathways by which their covalent structure can degrade. The remainder of the book is devoted to techniques used in the study of these two major areas of protein stability, as well as several areas of active research. Although some techniques, such as X-ray crystallography and mass spectroscopy, are used in the study of protein stability, they are beyond the scope of this book and will not be covered extensively.

Protein folding --- Proteins --- -Folding of proteins --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Conformation --- Folding --- Protein folding. --- Conformation. --- Protein conformation --- Folding of proteins --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- PROTEINS --- PROTEIN FOLDING --- CONFORMATION --- PROPERTIES

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This comprehensive text thoroughly explains basic biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. Contains a wealth of biochemical applications such as agricultural, pharmaceutical, medical and forensic. This edition has been updated to reflect the enormous advances in molecular and protein structure. Features increased emphasis on human disease, more end-of-chapter problems and extensive use of molecular biological techniques.

Biochemistry. --- 577.1 --- Biochemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- 577.1 Chemical bases of life. Biochemistry and bio-organic chemistry generally --- Chemical bases of life. Biochemistry and bio-organic chemistry generally --- Composition --- Biochemie. --- Biology --- Chemistry --- Medical sciences --- #WPLT:kand --- General biochemistry --- Biochimie --- Biochemistry - textbooks