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La protéine des cellules de Clara (CC16), microprotéine de 16kD sécrétée par les cellules non ciliées de l’arbre trachéo-bronchique et proposée récemment comme marqueur périphérique de toxicité pulmonaire, est évaluée chez des travailleurs d’une fonderie. La concentration de CC16 est mesurée dans le sérum et dans les expectorations de 47 ouvriers de fonderie et 41 ouvriers témoins appariés pour les habitudes tabagiques et l’indice de masse corporelle. Les travailleurs de fonderie sont exposés à des poussières minérales et métalliques ainsi qu’à des émanations gazeuses depuis 15.2 ans en moyenne. Aucune différence dans les symptômes respiratoires, les radiographies thoraciques et les épreuves fonctionnelles respiratoires n’apparaît entre les sujets témoins et exposés. En revanche, la concentration sérique de CC16 est, par rapport aux sujets témoins correspondants, significativement réduite chez les sujets exposés fumeurs et ex-fumeurs. On observe surtout une corrélation négative significative entre la concentration sérique de CC16 et l’empoussièrement actuel (r=0.66, p=0.0001) d’une part, et l’empoussièrement cumulé (r=0.52, p=0.0002) d’autre part. La détermination de la CC16/alpha amylase et appliquée sur 30 sujets témoins et 30 exposés, montre une diminution significative en fonction du tabagisme seul. Une légère influence du tabagisme (p=0.06) sur la concentration sérique de CC16 est également constatée mais on ne note aucune interaction significative avec l’empoussièrement. Les modifications des concentrations sériques de CC16 sont probablement consécutives à des effets toxiques précoces des polluants atmosphériques sur l’épithélium du tractus respiratoire. L’intérêt de l’utilisation de la CC16 comme marqueur périphérique de toxicité pulmonaire est confirmé par notre étude.

Biological Markers --- Lung Diseases --- Air Pollutants, Occupational --- Industry

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Environmental Exposure --- Lung --- Lung Diseases --- Child --- Air Pollutants --- Air Pollution, Indoor --- adverse effects --- physiology --- epidemiology

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Air quality control --- Air quality management --- Air quality--Management --- Luchtkwaliteit--Beheer --- Qualité de l'air--Gestion --- Smog --- Smog. --- Air --- Pollution. --- Pollution --- Health aspects --- Fog --- Smoke --- Smaze --- Air contaminants --- Air pollutants --- Air pollution --- Air pollution control --- Air toxics --- Airborne pollutants --- Atmosphere --- Contaminants, Air --- Control of air pollution --- Pollutants, Air --- Toxics, Air --- Air quality --- Atmospheric deposition --- Control

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These proceedings are based on the third of a series of symposia devoted to the use of catalysis for the depollution of exhaust gases of motor vehicles. Although catalysts have been used for this purpose for some thirty years, the subject is still very topical because of its economic impact. The increasing number of submitted, accepted and published papers amply attests to this fact.

ALTERNATIVE FUELS --- Traffic --- TRANSPORT --- CARS --- Catalyst technologies --- AIR POLLUTION --- Automotive pollution --- Monograph --- Communication and traffic. --- Transportation. --- Air --- Air contaminants --- Air pollutants --- Air pollution --- Air pollution control --- Air toxics --- Airborne pollutants --- Atmosphere --- Contaminants, Air --- Control of air pollution --- Pollutants, Air --- Toxics, Air --- Pollution --- Air quality --- Atmospheric deposition --- Public transportation --- Transport --- Transportation --- Transportation, Primitive --- Transportation companies --- Transportation industry --- Locomotion --- Commerce --- Communication and traffic --- Storage and moving trade --- Communications industries --- Mass communication --- Communication --- Pollution. --- Control --- Economic aspects --- Automobiles --- Catalysis --- Autos (Automobiles) --- Cars (Automobiles) --- Gasoline automobiles --- Motorcars (Automobiles) --- Motor vehicles --- Transportation, Automotive --- Catalytic converters --- Motors --- Exhaust gas

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State and federal regulations affecting hazardous air pollutants have produced an escalating dilemma for industrial facilities. While struggling to remain competitive and in compliance with environmental regulations, industry faces increasing requirements and potential liabilities due to emissions of hazardous air pollutants. Many states began establishing regulations governing the emissions of hazardous air pollutants after the 1984 accidental release of methyl isocyanate in Bhopal, India. After thirteen years of extended debate, the US Congress passed significant amendments to the Clean Air

Regional documentation --- United States --- Air --- Factory and trade waste --- Liability for air pollution damages --- Pollution. --- Environmental aspects --- United States. --- Air pollution damages, Liability for --- Liability for environmental damages --- Factory waste --- Industrial effluents --- Industrial wastes --- Solid waste management --- Trades-waste --- Wastewaters --- Plant engineering --- Centralized industrial waste treatment facilities --- Pollution --- Refuse and refuse disposal --- Waste products --- Air contaminants --- Air pollutants --- Air pollution --- Air pollution control --- Air toxics --- Airborne pollutants --- Atmosphere --- Contaminants, Air --- Control of air pollution --- Pollutants, Air --- Toxics, Air --- Air quality --- Atmospheric deposition --- Law and legislation --- Control