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Drug discovery : science and development in a changing society.
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ISBN: 0841201366 Year: 1971 Publisher: Washington (D.C.) American chemical society


Periodical
Critical reviews in microbiology
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ISSN: 1040841X 1040841X Year: 1971 Publisher: Boca Raton CRC.

Blood Cell Biochemistry.
Authors: ---
ISSN: 10780491 ISBN: 9780306452383 0306452383 9780585317281 1475770529 0585317283 Year: 1971 Volume: v. 7 Publisher: New York (N.Y.) Springer.

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Abstract

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).


Periodical
European journal of immunology.
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ISSN: 00142980 Year: 1971 Publisher: Weinheim Verl. Chemie,.

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Abstract

The European Journal of Immunology (EJI) is a basic immunology research journal, focusing on various aspects of immunology including but not limited to antigen processing, cellular immune response, immunity to infection, immunomodulation, innate immunity, molecular immunology, leukocyte signalling, clinical immunology, and new technology. Established in 1971, the Journal has been serving the needs of the immunology community worldwide with objective enthusiasm. While mechanistic insight, which helps us better understand the workings of the immune system is of great importance for EJI, we are also interested in studies that contain thought-provoking immunological findings.


Periodical
Biologie in unserer Zeit.
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ISSN: 1521415X 0045205X Year: 1971 Publisher: [Weinheim, Germany] : [Hoboken, NJ] : Bielefeld, Germany : Verlag Chemie, John Wiley & Sons Ltd. Association of Biology, Life Sciences and Biomedicine in Germany - VBIO eV


Periodical
The Hastings center report.
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ISSN: 00930334 1552146X Year: 1971 Publisher: Hastings-on-Hudson Hastings center

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Abstract

The Hastings Center Report explores the ethical, legal, and social issues in medicine, health care, public health, and the life sciences. Six issues are published each year, containing an assortment of essays, columns on legal and policy developments, case studies of issues in clinical care and institutional administration, caregivers’ stories, peer-reviewed scholarly articles, and book reviews. Authors come from an assortment of professions and academic disciplines and bring a range of perspectives and political opinions. We welcome submissions from new authors. The Report’s readership includes physicians, nurses, scholars of many stripes, administrators, social workers, health lawyers, and others.

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