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This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.

Medicine—Research. --- Biology—Research. --- Drug delivery systems. --- Vaccines—Biotechnology. --- Biomaterials. --- Immunotherapy. --- Biomedical Research. --- Drug Delivery. --- Biomaterials-Vaccines. --- Therapeutic immunology --- Clinical immunology --- Therapeutics --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Delivery systems --- Drug Delivery Systems. --- Vaccines. --- Spray Drying. --- Drying, Spray --- Spray Dryings --- Immunotherapies --- Combined Antibody Therapeutics --- Immunity, Active --- Immunologic Techniques --- Vaccine --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Dosage Forms --- Spray drying. --- Vaccines --- Biotechnology. --- Vaccine biotechnology --- Biotechnology --- Drying --- Spraying

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After spending over 12 years developing new microsystems for biotechnology û especially concerned with the microfluidic aspects of these devices û Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics.Engineers interested in designing more versatile microsystems and students who seek to learn the fundamentals of micro

Atomizers --- Drops --- Electrostatic atomization --- Microdroplets --- Microelectromechanical systems --- Microfluidics --- Spraying equipment --- 532.64 --- 544.722.3 --- 57.088 --- 631.347.3 --- 66.063.5 --- 66.069.832 --- Spraying --- Agricultural implements --- Agricultural machinery --- Gardening --- Fluidics --- Nanofluids --- MEMS (Microelectromechanical systems) --- Micro-electro-mechanical systems --- Micro-machinery --- Microelectromechanical devices --- Micromachinery --- Micromachines --- Micromechanical devices --- Micromechanical systems --- Electromechanical devices --- Microtechnology --- Mechatronics --- Atomization --- Drips --- Droplets --- Liquids --- Spheroidal state --- Nebulizers --- Perfumizers --- 57.088 Special methods and techniques for studing biological molecules. Separation. Centrifuging. X-ray study. Radioisotope methods --- Special methods and techniques for studing biological molecules. Separation. Centrifuging. X-ray study. Radioisotope methods --- 532.64 Wetting angle. Contact angle --- Wetting angle. Contact angle --- 66.063.5 Wetting. Moistening. Wetting agents --- Wetting. Moistening. Wetting agents --- 631.347.3 Spraying equipment. Sprinklers. Sprays, spray-guns, jets --- Spraying equipment. Sprinklers. Sprays, spray-guns, jets --- Methodology --- Equipment and supplies --- Wettability. Chemical nature of wetting. Spreading. Spreading ability --- Atomizing. Spraying. Atomizers and spraying devices --- Equipment --- Engineering --- Mechanical Engineering --- Atomizers. --- Microelectromechanical systems. --- Equipment and supplies. --- Methodology. --- Coating processes