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Low-Abundance Proteome Discovery addresses the most critical challenge in biomarker discovery and progress: the identification of low-abundance proteins. The book describes an original strategy developed by the authors that permits the detection of protein species typically found in very low abundance and that may yield valuable clues to future discoveries. Known as combinatorial peptide ligand libraries, these new methodologies are one of the hottest topics related to the study of proteomics and have applications in medical diagnostics, food quality, and plant analysis. The book is

Proteins - Analysis. --- Proteins -- Analysis. --- Proteomics. --- Proteomics - Methodology. --- Proteomics -- Methodology. --- Proteomics --- Proteins --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Methodology --- Analysis --- Methodology. --- Analysis. --- Molecular biology

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Nucleotide sequence --- Amino acid sequence --- Genes --- Proteins --- Séquence nucléotidique --- Séquence des acides aminés --- Gènes --- Protéines --- Databases. --- Data processing --- Analysis --- Data processing. --- Bases de données --- Informatique --- Analyse --- Base Sequence --- Amino Acid Sequence --- Databases, Factual --- Sequence Analysis --- Databases --- analysis --- #TELE:SISTA --- Base Sequence. --- Amino Acid Sequence. --- Amino acid sequence. --- Databases, Factual. --- Sequence Analysis. --- analysis. --- Séquence nucléotidique --- Séquence des acides aminés --- Gènes --- Protéines --- Bases de données --- Nucleotide sequence - Databases --- Amino acid sequence - Databases --- Genes - Analysis - Data processing --- Proteins - Analysis - Data processing --- Proteins - analysis --- MANUALS --- GENE MAPPING --- PROTEIN ANALYSIS --- BIOINFORMATICS --- AMINO ACID SEQUENCE --- PROTEINS --- MOLECULAR BIOLOGY --- GENES --- NUCLEOTIDE SEQUENCE --- COMPUTER TECHNIQUES --- STRUCTURES --- INTERNET --- ANALYSIS --- DATA PROCESSING --- DATABASES

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Proteins --- Nucleic acids --- Biotechnology. --- Analysis. --- Mass spectrometry. --- Mass spectrometry --- methods --- Ions --- Biotechnology --- peptides --- proteins --- Carbohydrates --- Nucleotides --- 57.08 --- #WDIR:vfm2 --- 543.51 --- Massaspectrometrie --- 57.08 Biological techniques. Experimental methods. Equipment --- Biological techniques. Experimental methods. Equipment --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Chemical engineering --- Genetic engineering --- Analysis --- Proteins - Analysis. --- Nucleic acids - Analysis.

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Capillary electrophoresis (CE) is one of the premier methods for the rapid analysis of pharmaceutical proteins and peptides, and thus now even more important with the sequencing of the human genome and the subsequent advent of proteomics. In Capillary Electrophoresis of Proteins and Peptides, leading academic scientists and expert laboratorians working in the pharmaceutical industry describe their best CE techniques in step-by-step detail for easy reproduction. The authors present cutting-edge techniques for both capillary coatings and analytical detection via laser-induced fluorescence, for the development and commercialization of biopharmaceuticals, and for affinity capillary electrophoresis in the evaluation of protein binding, including the use of protein charge ladders. Additional chapters discuss CE and capillary isoelectric focusing, combined with electrospray mass spectrometry detection, for performing proteomic studies. Areas of special interest covered include proteomic applications, as well as applications in the field of protein-ligand binding. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Capillary Electrophoresis of Proteins and Peptides will prove essential to both new and experienced investigators carrying out significant protein and peptide studies in biotechnology, drug discovery, and pharmaceutical research and development.

Capillary electrophoresis --- Proteins --- Peptides --- Electrophoresis, Capillary --- Separation --- methods --- analysis --- Capillary electrophoresis -- Laboratory manuals. --- Peptides -- Separation -- Laboratory manuals. --- Proteins -- Separation -- Laboratory manuals. --- Electrophoresis --- Amino Acids, Peptides, and Proteins --- Investigative Techniques --- Chemistry Techniques, Analytical --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Electrochemical Techniques --- Methods --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Organic compounds --- Amino acids --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Capillary gel electrophoresis --- Capillary zone electrophoresis --- Gel electrophoresis --- Zone electrophoresis --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Capillary electrophoresis - Laboratory manuals --- Proteins - Separation - Laboratory manuals --- Peptides - Separation - Laboratory manuals --- Electrophoresis, Capillary - methods --- Proteins - analysis

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The Phylogenetic Handbook is a broad, hands on guide to theory and practice of nucleotide and protein phylogenetic analysis. This second edition includes six new chapters, covering topics such as Bayesian inference, tree topology testing and the impact of recombination on phylogenies, as well as a detailed section on molecular adaptation. The book has a stronger focus on hypothesis testing than the previous edition, with more extensive discussions on recombination analysis, detecting molecular adaptation and genealogy-based population genetics. Many chapters include elaborate practical sections, which have been updated to introduce the reader to the most recent versions of sequence analysis and phylogeny software, including BLAST, FastA, Clustal, T-coffee, Muscle, DAMBE, Tree-puzzle, Phylip, MEGA, PAUP*, IQPNNI, CONSEL, ModelTest, Prottest, PAML, HYPHY, MrBayes, BEAST, LAMARC, SplitsTree, and RDP. Many analysis tools are described by their original authors, resulting in clear explanations that constitute an ideal teaching guide for advanced-level undergraduate and graduate students.

Evolution. Phylogeny --- Sequence Analysis, DNA --- Sequence Analysis, Protein --- Phylogenèse --- Models, Genetic. --- DNA phylogeny --- Amino Acid Sequence. --- -Proteins --- fylogenetica --- dna analyse --- 575.852 --- 575.852 Biomacromolecules. Molecular evolution --- Biomacromolecules. Molecular evolution --- Branching processes --- Amino Acid Sequences --- Sequence, Amino Acid --- Sequences, Amino Acid --- Protein Structure, Primary --- Primary Protein Structure --- Primary Protein Structures --- Protein Structures, Primary --- Structure, Primary Protein --- Structures, Primary Protein --- Phylogenies --- Models, genetic. --- Sequence analysis, dna --- Sequence analysis, protein --- Phylogenèse --- Phylogeny --- methods --- Computer programs. --- Amino acid sequence --- Cladistic analysis --- DNA --- Proteins --- Models, Genetic --- aminozuur --- dna --- proteine --- Academic collection --- 577.112 --- 577.212.3 --- 577.212.3 Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code. --- Classification --- Phylogeography --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Deoxyribose --- Nucleic acids --- Genes --- Cladism --- Cladistic method --- Cladistic taxonomy --- Cladistics --- Cladograms --- Phylogenetic systematics --- Phylogenetic taxonomy --- Taxonomy, Cladistic --- Taxonomy, Phylogenetic --- Biology --- Amino acid sequence analysis --- Analysis, Amino acid sequence --- Peptide sequence --- Peptide sequencing --- Protein sequence --- Protein sequencing --- Sequence, Amino acid --- Amino acids --- Sequence alignment (Bioinformatics) --- Genetic Models --- Genetic Model --- Model, Genetic --- 577.112 Proteins --- Data processing --- Analysis --- Nucleic acid base and sequence compositon. Experimental deciphering of genetic code --- Phylogenomics --- Phylogenomic --- Dna --- Phylogeny. --- Data processing. --- Methods. --- methods. --- Community Phylogenetics --- Molecular Phylogenetics --- Phylogenetic Analyses --- Phylogenetic Analysis --- Phylogenetic Clustering --- Phylogenetic Comparative Analysis --- Phylogenetic Comparative Methods --- Phylogenetic Distance --- Phylogenetic Generalized Least Squares --- Phylogenetic Groups --- Phylogenetic Incongruence --- Phylogenetic Inference --- Phylogenetic Networks --- Phylogenetic Reconstruction --- Phylogenetic Relatedness --- Phylogenetic Relationships --- Phylogenetic Signal --- Phylogenetic Structure --- Phylogenetic Tree --- Phylogenetic Trees --- Analyse, Phylogenetic --- Analysis, Phylogenetic --- Analysis, Phylogenetic Comparative --- Clustering, Phylogenetic --- Community Phylogenetic --- Comparative Analysis, Phylogenetic --- Comparative Method, Phylogenetic --- Distance, Phylogenetic --- Group, Phylogenetic --- Incongruence, Phylogenetic --- Inference, Phylogenetic --- Method, Phylogenetic Comparative --- Molecular Phylogenetic --- Network, Phylogenetic --- Phylogenetic Analyse --- Phylogenetic Clusterings --- Phylogenetic Comparative Analyses --- Phylogenetic Comparative Method --- Phylogenetic Distances --- Phylogenetic Group --- Phylogenetic Incongruences --- Phylogenetic Inferences --- Phylogenetic Network --- Phylogenetic Reconstructions --- Phylogenetic Relatednesses --- Phylogenetic Relationship --- Phylogenetic Signals --- Phylogenetic Structures --- Phylogenetic, Community --- Phylogenetic, Molecular --- Reconstruction, Phylogenetic --- Relatedness, Phylogenetic --- Relationship, Phylogenetic --- Signal, Phylogenetic --- Structure, Phylogenetic --- Tree, Phylogenetic --- Molecular evolution --- Nucleotides --- Nucleotide sequence --- Molecular aspects --- DNA - Analysis - Handbooks, manuals, etc --- Proteins - Analysis - Handbooks, manuals, etc --- Cladistic analysis - Handbooks, manuals, etc --- Amino acid sequence - Data processing --- Filogènia --- Evolució molecular --- Seqüència de nucleòtids --- Informàtica. --- Aspectes moleculars