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Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research.

Ion channels.

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Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well.Key Features* Comprehensive protocols included for the study of: * I

Electrophysiology --- Ion channels --- Muscle cells. --- Neurons. --- Physiology.

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This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells from the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse function including secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, researches on ion channels carry significant meaning for the understanding of basic protein biophysics and diverse physiological functions and for developing novel and effective treatment for related human diseases. This book could provide graduates and scientists in both basic and clinical levels, a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.

Histology. Cytology --- Biology --- Human physiology --- celmembranen --- biologie --- fysiologie --- Ion channels. --- Ion channels --- Canals iònics --- Biologia --- Fisiologia --- Research --- Methodology. --- Biologia.

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Histology. Cytology --- Biology --- Human physiology --- celmembranen --- biologie --- fysiologie --- Ion channels. --- Ion channels --- Research --- Methodology. --- Channels, Ion --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Canals iònics --- Biologia --- Fisiologia

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The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equili

Chloride channels. --- Chlorides --- Physiological transport. --- Chlorine compounds --- Halides --- Channels, Chloride --- Ion channels