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Human biochemistry --- Pharmacology. Therapy --- Prostaglandins --- Thromboxanes --- Contracting substance, Rabbit aorta --- Rabbit aorta contracting substance --- Prostanoids --- Inflammation --- analysis --- Mediators --- Thromboxane --- Prostaglandin --- Prostanoid

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Cocoa and chocolate are the subjects of much research in the fields of food chemistry, food technology, and health science. We now know that cocoa contains a remarkable number of bioactive compounds, and these are being tested in humans to verify their disease prevention characteristics. This state of the art text thoroughly explores the different aspects of the relationship between chocolate and health. After introductory discussion of the historical background, careful attention is devoted to technological developments designed to improve the health-giving qualities of chocolate and biochemical and clinical trials of cocoa and its components. Various health impacts of cocoa and chocolate are thoroughly evaluated, including acute vascular effects and effects on blood pressure, blood lipids, and platelets. Psychological drivers of chocolate consumption and craving are also considered. Readers will find this book to be a rich source of essential information on cocoa and chocolate, their purported health-giving qualities, and the advances that are being made in this area.

Hygiene. Public health. Protection --- Physiotherapy. Alternative treatments --- Pharmacology. Therapy --- Pathology of the circulatory system --- Food science and technology --- preventieve gezondheidszorg --- farmacologie --- toxicologie --- gezondheidspromotie --- voedingsleer --- cardiologie --- alternatieve geneeswijzen

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The central nervous system represents the organ with the highest structural and functional complexity. Uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. This book provides an overview of some major facets of research on Drosophila brain development.

Biomedicine. --- Biomedicine general. --- Medicine. --- Médecine --- Brain --- Developmental neurobiology. --- Drosophila melanogaster --- Growth. --- Development. --- embryology. --- growth & development. --- Brain -- Embryology. --- Brain -- Growth. --- Drosophila melanogaster -- Development. --- Drosophila melanogaster -- Growth & development. --- Developmental neurobiology --- Physiological Processes --- Anatomy --- Central Nervous System --- Drosophila --- Nervous System --- Drosophilidae --- Physiological Phenomena --- Biological Science Disciplines --- Phenomena and Processes --- Natural Science Disciplines --- Diptera --- Insects --- Disciplines and Occupations --- Arthropods --- Invertebrates --- Animals --- Eukaryota --- Organisms --- Growth and Development --- Embryology --- Zoology --- Health & Biological Sciences --- Invertebrates & Protozoa --- Development --- Growth --- Developmental neurology --- Neurogenesis --- Drosophila ampelophila --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Developmental biology --- Neurobiology --- Nervous system --- Neuroplasticity --- Evolution --- Health Workforce --- Embryology. --- Growth & development. --- Biomedicine, general.

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If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas' disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.

General parasitology --- parasitologie

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Immunological recognition is a central feature of the adaptive immunity of vertebrates. With the exception of agnathans, which developed an entirely distinct set of immunologically-specific molecules, all vertebrates use a recognition system based on what Achsah Keegan and I suggested in 1992 be termed multichain immune recognition receptors (MIRRs). MIRRs consist of ligand-binding molecules that are immunoglobulin supergene family members associated with signal transducers and enhancers in such a way as both insure precise ligand recognition, discrimination and ampHfication of the signal. Two of the prototypic sets of MIRRs, the T-cell and B-cell receptors, are among the most remarkable recognition molecules known. These are extraordinarily diverse molecules in which the range of ligands that can be potentially recognized prob­ ably exceeds the actual numbers of lymphocytes in the body. The discovery of the genetic basis of assembling these receptors and understanding how they bind to their cognate antigens are among the most stunning of scientific achievements. Yet these immensely specific binding chains (the heavy/light chain pair for immunoglobulin and the a/p chain pair for most T cells), when expressed as membrane molecules, have no obvious mechanism of signaling. For example, the |iH chain cytosolic do­ main consists of three amino acids (lysine-valine-lysine) and the L chain is not even embedded in the membrane. Furthermore, there is no known direct mechanism to propagate information from the binding domain of the B-cell or T-cell receptors to the membrane-proximal domains of the same chains.

Human biochemistry --- medische biochemie --- biochemie