Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Chemotherapy. --- Chemotherapy --- Social aspects. --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Biomathematics. Biometry. Biostatistics --- General biochemistry --- bio-informatica --- biochemie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Genetics --- Human biochemistry --- Human genetics --- nucleïnezuren --- medische biochemie --- medische genetica --- genetica

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

For this RNA Technologies volume a world-wide outstanding group of RNA specialists are contributing the most recent developments in this fast moving field of RNA molecular biology. The book features up-to-date information of our current knowledge on antisense, ribozyme, micro RNA, and DNAzyme strategies, as well as on other small RNAs from eukaryotes and prokaryotes, and the employment of chemical modifications to stabilize ribonucleic acids for their use in living cells. This volume is not only excellent reading for the expert in the field of RNA technologies, but also for those interested in entering this field as a chemist, molecular biologist or as a medical doctor interested in RNA therapeutics of the future.

Organic chemistry --- Molecular biology --- Human genetics --- RNA (ribonucleic acid) --- organische chemie --- medische genetica --- genetica --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- moleculaire biologie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.

Pharmacology. Therapy --- farmacologie --- toxicologie