Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

database --- Integrative strategies --- molecular docking --- polypharmacology --- multi-omics --- computational analysis --- Drug Repositioning --- data sharing --- Patenting

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is a collection of original research articles in the field of computer-aided drug design. It reports the use of current and validated computational approaches applied to drug discovery as well as the development of new computational tools to identify new and more potent drugs.

3D-QSAR --- pharmacophore modeling --- ligand-based model --- HDACs --- isoform-selective histone deacetylase inhibitors --- aminophenylbenzamide --- hERG toxicity --- drug discovery --- fingerprints --- machine learning --- deep learning --- gene expression signature --- drug repositioning approaches --- RNA expression regulation --- high-throughput virtual screening --- dual-target lead discovery --- neurodegenerative disorders --- Alzheimer’s disease --- dual mode of action --- multi-modal --- nicotinic acetylcholine receptor --- acetylcholinesterase --- molecular docking --- methotrexate --- drug resistance --- human dihydrofolate reductase --- virtual screening --- molecular dynamics simulation. --- epitope binning --- epitope mapping --- epitope prediction --- antibody:antigen interactions --- protein docking --- glycoprotein D (gD) --- herpes simplex virus fusion proteins --- Src inhibitors --- pharmacophore model --- molecular dynamics simulations --- in silico --- COX-2 inhibitors --- molecular modeling --- sodium–glucose co-transporters 2 --- FimH --- uropathogenic bacteria --- urinary tract infections --- diabetes --- drug-resistance mutations --- HIV-2 protease --- structural characterization --- induced structural deformations --- SARS-CoV-2 --- COVID-19 --- multiprotein inhibiting natural compounds --- MD simulation --- 3CL-Pro --- antivirals --- docking simulations --- drug repurposing --- consensus models --- binding space --- isomeric space --- MRP4 --- SNPs --- variants --- protein threading modeling --- molecular dynamics --- binding site --- hTSPO --- PK11195 --- cholesterol --- homology modeling --- molecular dynamics (MD) simulation --- carbon nanotubes --- Stone–Wales defects --- haeckelite defects --- doxorubicin encapsulation --- drug delivery system --- binding free energies --- noncovalent interactions --- main protease --- mutants --- inhibitors --- PF-00835231 --- Mycobacterium tuberculosis --- tuberculosis --- proteasome --- natural compounds --- multiscale --- multitargeting --- polypharmacology --- computational biology --- drug repositioning --- structural bioinformatics --- proteomic signature --- skin aging --- oxidative stress --- aging progression mechanism --- genome-wide genetic and epigenetic network (GWGEN) --- systems medicine design --- multiple-molecule drug --- immunoproteasome --- non-covalent inhibitors --- MD binding --- metadynamics --- induced-fit docking --- n/a --- Alzheimer's disease --- sodium-glucose co-transporters 2 --- Stone-Wales defects

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book contains 10 reviewed papers published as a Special Issue “Global and International Logistics” in the journal Sustainability, edited by Prof. Dr. Ryuichi Shibasaki, Prof. Dr. Daisuke Watanabe, and Dr. Tomoya Kawasaki. The topics of the papers contain the impact of logistics development under the China’s Belt and Road initiative (BRI) by using the improved gravity model, strategies against barriers to the BRI from a logistics and supply chain management perspective, the dynamic interaction between international logistics, and cross-border e-commerce trade, the effect of China’s restrictive programs on the international trade of waste products, the empty container repositioning problem of shipping companies with foldable containers, port capacity and connectivity improvement in the hub and feeder network in Indonesia, GHG emission scenarios for the maritime shipping sector using system dynamics, incorporating a shipping and shipbuilding market model, the emission inventory and bunker consumption from a LNG fleet from an automatic identification system database, the factors that can help select between land transport and maritime shipping in long-distance inter-regional cross-border transport, and container transport simulations in Myanmar with the global logistics intermodal network assignment model including both maritime shipping and land transport in the land-based Southeast Asia region. Some papers are related to the 8th International Conference on Transportation and Logistics (T-LOG 2020) which was held online on 6–7 September 2020 hosted by Universitas Internasional Semen Indonesia.

Belt and Road Initiative --- New Silk Road --- One Belt One Road --- international logistics networks --- Nominal Group Technique --- scenario analysis --- global logistics simulation --- intermodal freight transport network --- economic corridor --- Myanmar --- terrestrial ASEAN --- Greater Mekong Subregion --- East–West Corridor --- Southern Corridor --- Dawei port --- GLINS model --- waste plastic --- used paper --- import ban --- import license --- international waste trade --- liquified natural gas (LNG) --- Automatic Identification System (AIS) --- spatial analysis --- greenhouse gases (GHGs) --- bunker --- emissions --- land transport --- cross-border land corridor --- Tobit model --- international logistics --- cross-border e-commerce trade --- panel vector error correction model --- sustainable development --- logistics development level --- international trade --- gravity model --- China --- the Belt and Road Initiative --- GHG emission measures --- international shipping --- system dynamics --- scenario planning --- deceleration operation --- energy efficiency design index --- LNG fuel --- zero-emission ships --- container port --- connectivity --- investment --- port cluster --- maritime container shipping --- empty container repositioning --- foldable containers --- Pacific Islands --- static analysis --- consecutive analysis --- demand fluctuation --- n/a --- East-West Corridor