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It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.

alpha-synuclein --- NMR --- secondary structure propensity --- pre-structured motifs (PreSMos) --- intrinsically disordered protein --- ubiquitin-proteasome system --- intrinsically disordered proteins --- protein misfolding --- molecular recognition features --- cancer --- neurodegenerative diseases --- protein degradation --- EPR spectroscopy --- isothermal titration calorimetry --- protein-ligand interaction --- site-directed spin labeling --- protein structural dynamics --- WASp interacting protein --- protein–protein interactions --- actin --- cytoskeleton remodeling --- SH3 domain --- proline-rich motif --- single nucleotide variants --- interface core and rim --- human disease --- intrinsically disordered regions --- linear motifs --- gene duplications --- de novo --- evolutionary origin --- circular dichroism --- flexibility --- fluorescence --- importin --- isothermal titration calorimetry (ITC) --- molecular docking --- nuclear magnetic resonance (NMR) --- nuclear protein 1 (NPR1) --- peptide --- Methyl-CpG-binding protein 2 (MeCP2) --- Rett syndrome --- intrinsically disordered protein (IDP) --- protein stability --- protein-DNA interaction --- proteostasis --- ubiquitin independent degradation --- NADH-26S proteasome --- n/a --- protein-protein interactions

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The Special Issue presents information on the progress made in recent years in cereals’, legumes’, and oilseed grain products’ rheology and quality. This Special Issue capitalizes the experience of authors in grain processing for obtaining food products qualitatively improved based on the quality of raw materials used and applied technologies or intended for special nutrition, such as gluten-free one or with low sodium content. This Special Issue also presents some issues related to byproduct valorization through circular economy approaches obtained from the processing of different cereals and oilseeds grains and new methods for rapid assessment of bread quality.

KCl --- NaCl --- rheological properties --- multiple criteria optimization --- desirability functions --- brewer’s spent grain --- bioeconomy --- valuable compounds --- germination process --- legumes --- technological process --- bread quality --- bread --- water content --- Karl Fischer titration --- KFT kinetics --- principal component analysis --- hybrid wheat --- bread-making quality --- N fertilisation --- Lactobacillus plantarum ATCC 8014 --- nutritional effects --- gluten-free muffins --- quinoa flour --- particle size --- optimization --- residues --- sustainability --- oil cake --- bioactive compounds --- edible films --- wheat straws --- pretreatment --- hydrolysis --- fermentation --- bioethanol --- wheat --- triticale --- sourdough --- Mixolab --- buckwheat flour --- buckwheat sprouts --- buns --- quality and textural parameters --- sorghum seeds --- whole wheat flour --- Lactobacillus plantarum --- soy protein concentrate --- pea protein concentrate --- texture --- sensory --- craft beer --- gluten-free beer --- functional beer --- adjuvants --- malted cereals --- gluten-free flour --- gram --- plantain --- chickpea --- tiger nut --- pseudo-cereal --- oat --- millet --- teff --- rice --- soybean sprouts --- chitooligosaccharide --- phytochemicals --- antioxidant activity --- catalase --- peroxidase --- n/a --- brewer's spent grain

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Rheumatoid Arthritis (RA) is a chronic inflammatory disease leading to joint inflammation and destruction. Treatment of RA includes the use of conventional (cs), biologic (b) disease-modifying anti-rheumatic drugs (DMARDs), and oral or intraarticular (IA) glucocorticoids (GCs). All different classes of drugs have shown to halt disease progression in clinical studies. In real life, a physician has more options than just adding or switching to a new ts/bDMARD if any kind of DMARDs has failed. They can modify or optimize the therapy with concomitant csDMARDs, and oral or IA-GC can be added to the treatment regimen. The EULAR states that therapeutic adjustment including the "optimization of csDMARDs dose or route of administration or intra-articular injections of GCs" is recommended. Thus, a new therapeutic agent can be embedded in a whole strategy with parallel optimization of the csDMARD and GC treatment. The idea of treating to target (T2T) for the treatment of RA patients has been around since the late 1990s. Many clinical studies (Ticora, BsSt, Camera) have demonstrated the superiority of a T2T approach. When I talk to physicians, I understand that most of them only rarely inject joints with GC. Therefore, I would like to create an issue on the T2T approach in reality including primary data, reviews, and real-life data demonstrating the general opinion and execution of T2T in treating RA.

rheumatoid arthritis --- sleep --- sleep disorders --- pain --- osteoporosis --- fracture --- fracture risk assessment tool --- treat-to-target --- certolizumab pegol --- csDMARDs --- glucocorticoids --- intra-articular injections --- DAS 28 --- ACR response --- HAQ-DI --- TNFα --- golimumab --- efficacy --- tolerability --- immunogenicity --- methotrexate --- posology --- titration --- oral route --- subcutaneous route --- bioavailability --- effectiveness --- periodontitis --- periodontal disease --- anti-citrullinated protein autoantibodies --- rheumatoid factor --- smoking --- medication --- Porphyromonas gingivalis --- Rheumatoid arthritis --- matrix metalloproteinase 3 --- infliximab --- pharmacogenomics --- anti-TNF --- personalized medicine --- baricitinib --- disease-modifying antirheumatic drugs --- pain perception --- outcomes research --- patient perspective --- Rheumatoid Arthritis --- therapy --- DMARD --- MTX --- Tumor Necrosis Factor-Alpha Inhibitors --- ankylosing spondylitis --- biosimilar --- switching --- synovial fibroblasts --- cytokine --- osteoclast --- herbal medicine --- methylation --- next-generation sequencing --- recovery of function --- fatigue --- productivity --- tofacitinib --- oral --- Th1.17 --- IL-17A --- IFN-γ, CD73 --- adenosine --- psoriatic arthritis --- regulation --- pseudoerosions --- hand --- foot --- ultrasonography --- radiography --- computed tomography --- magnetic resonance imaging --- n/a

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Flow analysis is an automatic, precise and fast way to perform analytical tests. Flow instruments are used for clinical and pharmaceutical analyses, quality control of industrial products, monitoring of environmental pollution and many other fields. The book presents the latest methodological, technical and instrumental achievements in flow analysis. It shows new possibilities for the miniaturization and full mechanization of flow systems, together with examples of their interesting application. The proposed solutions contribute to reducing the amount of used reagents and waste, as well as increasing the safety of working with hazardous reagents, resulting in modern devices operating in accordance with the principles of green chemistry. A number of innovative methods of processing and measuring analytical samples have also been described. The book very well reflects the current state of flow analysis and development directions.

cholesterol --- serum samples --- lab-on-valve --- automation --- enzymatic reaction --- neonicotinoid --- thiacloprid --- solid-phase spectroscopy --- optosensor --- luminescence --- bioaccessibility --- dog food --- dog nutrition --- dynamic extraction --- flow analysis --- kinetic profile --- zinc --- nuclear waste --- spent nuclear fuel --- ß-emitting nuclides --- 90Sr --- flow injection --- ICP-DRC-MS --- flow synthesis --- flow reactors --- flow-injection analysis --- flow techniques --- radionuclides --- radiochemical separation --- environmental monitoring --- nuclear emergency preparedness --- radioactive waste characterization --- medical isotope production --- titration --- Fe(III), Fe(II) determination --- speciation analysis --- Lab-In-Syringe --- automation of sample pretreatment --- potentials and troubles --- system setup and operation modes --- tips and tricks in method development --- 3D printing of instrument elements --- histidine --- random human urine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- fluorimetry --- SI-LAV --- mono-segmented flow --- in-line dilution --- in-line single-standard calibration --- in-line standard addition --- albumin --- glucose --- creatinine --- flow method --- chitosan --- catalyst particles --- micron-size --- sampling study --- p-nitrophenol reduction --- preconcentration --- evaporation --- sequential injection analysis --- paired emitter–detector diode detector --- contactless conductivity detector --- flow-based analysis --- simultaneous detection --- sequential detection --- flow chemistry