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DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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cell biology --- nanotechnology --- applied computation and bioinformatics --- structural biology --- structural chemistry --- Biology --- Life sciences --- Chemistry --- Sciences de la vie --- Chimie

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The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Central nervous system --- Physiology. --- Nervous system, Central --- Nervous system --- Life Sciences --- Immunology and Microbiology --- Structural Biology --- Proteomics

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Life Sciences --- Chemistry --- Health Sciences --- Biology --- Biochemistry --- Medical Education, Training & Research --- General and Others --- Molecular biology --- Molecular Biology. --- Macromolecular Substances. --- Models, Structural. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Model, Structural --- Structural Model --- Structural Models --- Macromolecular Complexes --- Macromolecular Compounds --- Macromolecular Compounds and Complexes --- Complexes, Macromolecular --- Compounds, Macromolecular --- Substances, Macromolecular --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Structural Biology. --- structural biology --- macromolecules --- Biophysics --- Biomolecules --- Systems biology --- Nanostructures --- Genetic Phenomena

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Biology --- Biologie --- Periodicals. --- Périodiques --- Biology. --- Life Sciences --- Animal Physiology --- Cytology, Cell Biology --- Micro and Molecular Biology --- biology --- Life sciences --- Biomass --- Life (Biology) --- Natural history --- Périodiques. --- Biological Sciences. --- aerobiology --- agricultural sciences --- anatomy and morphology --- behavior --- biochemistry --- biogenesis --- biogeography --- bioinformatics --- biological properties and phenomena --- biomathematics --- botany --- cell biology --- cryobiology --- embryology --- endocrinology --- evolutionary biology --- genetics --- histology --- immunology --- ionomics --- life history --- microbiology --- molecular biology --- mycology --- natural history --- neontology --- nutrition --- organisms --- paleontology --- parasitology --- photobiology --- physiology --- psychology --- sociobiology --- structural biology --- synthetic biology --- taxonomy --- zoology --- biologists --- hematology --- laboratory techniques --- Biologie. --- biology. --- Molecular biology --- Human genetics