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Inflammation --- Cellular signal transduction --- Inflammation. --- Signal Transduction. --- Pathology

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Human histology. Human cytology --- Molecular biology --- Cytology --- Cellular control mechanisms --- Proteins --- Cytologie --- Régulation cellulaire --- Protéines --- Periodicals --- Périodiques --- Cellular signal transduction --- Signal Transduction. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Bioenergetics --- Information theory in biology --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Histology. --- Cell Signaling --- moleculaire biologie

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Plant ecophysiology --- Plant cellular signal transduction --- Plant cellular signal transduction. --- Plant ecophysiology. --- Plant Physiological Phenomena. --- Plant Development. --- Signal Transduction. --- Environmental plant physiology --- Physiological plant ecology --- Plant physiological ecology --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Plant Morphogenesis --- Development, Plant --- Developments, Plant --- Morphogeneses, Plant --- Morphogenesis, Plant --- Plant Developments --- Plant Morphogeneses --- Plants --- Physiology, Plant --- Plant Physiologic Phenomena --- Plant Physiologic Phenomenon --- Plant Physiological Phenomenon --- Plant Physiological Process --- Plant Physiological Processes --- Plant Physiology --- Phenomena, Plant Physiologic --- Phenomena, Plant Physiological --- Phenomenon, Plant Physiologic --- Phenomenon, Plant Physiological --- Phenomenons, Plant Physiological --- Physiologic Phenomena, Plant --- Physiologic Phenomenon, Plant --- Physiological Phenomena, Plant --- Physiological Phenomenon, Plant --- Physiological Phenomenons, Plant --- Physiological Process, Plant --- Physiological Processes, Plant --- Plant Physiological Phenomenons --- Process, Plant Physiological --- Processes, Plant Physiological --- growth & development --- physiology --- Plant Physiological Phenomena --- Plant Development --- Signal Transduction --- Ecophysiology --- Plant ecology --- Plant physiology --- Cellular signal transduction --- Plant cellular control mechanisms --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Life Sciences --- Botany --- Cell Signaling

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Members of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. Most PKC proteins are ubiquitously expressed and participate in a plethora of functions in most cell types. A majority of PKC isoforms is also expressed in cells of the immune system in which they are involved in signal transduction downstream of a range of surface receptors, including the antigen receptors on T and B lymphocytes. PKC proteins are central to signal initiation and propagation, and to the regulation of processes leading to immune cell proliferation, differentiation, homing and survival. As a result, PKC proteins directly impact on the quality and quantity of immune responses and indirectly on the host resistance to pathogens and tendency to develop immune deficiencies and autoimmune diseases. A significant progress was made in recent years in understanding the regulation of PKC enzymes, their mechanism of action and their role in determining immunocyte behavior This volume reviews the most significant contributions made in the field of immune cell regulation by PKC enzymes. Several manuscripts are devoted to the role of distinct PKC isoforms in the regulation of selected immunocyte responses. Additional manuscripts review more general mechanisms of regulation of PKC enzymes, either by post-translational modifications, such as phosphorylation or controlled proteolysis, or by interaction with different binding proteins that may alter the conformation, activity and subcellular location of PKC. Both types of mechanisms can introduce conformational changes in the molecule, which may affect its ability to interact with cofactors, ATP, or substrates. This topic will be followed by a discussion on the positive and negative impact of individual PKC isoforms on cell cycle regulation. A second section of this volume concentrates on selected topics relevant to role of the novel PKC isoform, PKC-theta, in T lymphocyte function. PKC-theta plays important and some non-redundant roles in T cell activation and is a key isoform that recruits to the immunological synapse - the surface membrane area in T cells that comes in direct contact with antigen presenting cells. The immunological synapse is formed in T cells within seconds following the engagement of the TCR by a peptide-bound MHC molecule on the surface of antigen-presenting cells. It serves as a platform for receptors, adaptor proteins, and effector molecules, which assemble into multimolecular activation complexes required for signal transduction. The unique ability of PKC-theta to activate the NF-kB, AP-1 and NF-AT transcription factors is well established, and recent studies contributed essential information on the mechanisms involved in the recruitment of PKC-theta to the center of the immunological synapse and the nature of its substrates and the role of their phosphorylated forms in signal transduction. Additional review manuscripts will describe the unique behavior of PKC-theta in regulatory T cells and its role in the regulation of other cell populations, including those of the innate immune response. This volume brings together leading experts from different disciplines that review the most recent discoveries and offer new perspectives on the contributions of PKC isoforms to biochemical processes and signaling events in different immune cell populations and their impact on the overall host immune response.

T cell activation --- lymphocyte stimulation --- cell growth regulation --- Protein Kinase C --- signal transduction pathways

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

signal transduction --- ACTH --- G protein --- beta-arrestin --- sertolli cells --- gonadotroph cell --- myometrium contractility --- TSH receptor