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The present reprint contains twelve papers published in the Special Issue “Advances in Discrete Applied Mathematics and Graph Theory, 2021” of the MDPI Mathematics journal, which cover a wide range of topics connected to the theory and applications of Graph Theory and Discrete Applied Mathematics. The focus of the majority of papers is on recent advances in graph theory and applications in chemical graph theory. In particular, the topics studied include bipartite and multipartite Ramsey numbers, graph coloring and chromatic numbers, several varieties of domination (Double Roman, Quasi-Total Roman, Total 3-Roman) and two graph indices of interest in chemical graph theory (Sombor index, generalized ABC index), as well as hyperspaces of graphs and local inclusive distance vertex irregular graphs.

dominating set --- total roman {3}-domination --- NP-complete --- linear-time algorithm --- Ramsey numbers --- multipartite Ramsey numbers --- stripes --- paths --- cycle --- ABC index --- generalizedABC index --- general Randić index --- topological indices --- converse Hölder inequality --- local antimagic labeling --- local antimagic chromatic number --- copies of graphs --- hyperspace --- graph --- dendroid --- dendrite --- (inclusive) distance vertex irregular labeling --- local (inclusive) distance vertex irregular labeling --- quasi-total Roman domination --- total Roman domination --- Roman domination --- double Roman domination --- generalized Petersen graph --- discharging method --- graph cover --- double Roman graph --- topological index --- vertex degree --- Sombor index --- cactus --- quasi-unicyclic graph --- bipartite Ramsey numbers --- Zarankiewicz number --- total coloring --- dumbbell maximal planar graphs --- I-dumbbell maximal planar graphs --- dumbbell transformation --- total coloring algorithm --- domination coloring --- domination chromatic number --- split graphs --- generalized Petersen graphs --- corona products --- edge corona products