Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Knowledge of the structure and function of the complex and interwoven network of nerves is inexhaustible and has not been fully determined. The physiological basis of many neuropathic symptoms continues to pursue experts in this field, and in many of the pathological changes related to neuropathies. In the last few decades, there has been increasing interest in new tools applied to diseases involving nerves of the nervous system, which have changed this state of affairs. Microscopic studies, new quantitative histometric methods, and refined physiologic techniques have already expanded our knowledge of structure and function of nerves and rapidly advancing techniques in the fields of immunology and molecular genetics to clarify entire categories of polyneuropathy. Although polyneuropathy is among the most challenging categories of neurological diseases, effective forms of treatment for polyneuropathy have been introduced during the last few decades. This book intends to provide the reader with a broad overview of polyneuropathy, featuring considerations and diagnostic approaches to patients, specific neuropathic syndromes and new related entities, pathogenic mechanisms, and pathological reactions brought to bear to the therapeutic and new clinical applications. All this is important evidence to support present and future directions in this challenging topic.

Peripheral vascular diseases. --- Peripheral vascular disease --- Vascular diseases --- Blood-vessels --- Diseases --- Neurology & clinical neurophysiology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems.

hypersensitivity pneumonitis --- metalloproteinases --- genetic association --- autoantibodies --- MMP1 --- MMP2 --- SNPs --- MMPs --- TIMPs --- CKD --- peripheral vascular disease --- biomarkers --- proteinuria --- eGFR --- PAD. --- NGAL --- statins --- arterial aneurysms --- patients --- collagenases --- Crohn’s disease --- dental caries --- mouth --- periodontitis --- matrix metalloproteinase-9 --- dialysis --- on-line hemodiafiltration --- high-flux dialysis --- renal replacement therapy --- kidney transplantation --- Mac-1 --- CD147 --- leukocytes --- platelets --- adhesion --- integrin αMβ2 --- matrix metalloproteinases --- TIMP --- synthetic inhibitors --- RECK --- matrix metalloproteinase --- MAPKs --- ischemia/reperfusion --- eNOS --- iNOS --- inflammatory bowel disease --- inflammation --- NO --- MMP-9 --- cGMP --- Caco-2 --- matrix metalloproteinase-7 --- fibrosis --- acute kidney injury --- chronic kidney disease --- apoptosis --- health --- disease