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In deze publicatie bespreken we eerst wat de interne klachtenbehandeling van interne of externe klagers inhoudt. Vervolgens kaderen we de interne klachtenbehandeling op de verschillende bestuursniveau’s: het federale bestuursniveau; het Vlaamse bestuursniveau; het niveau van de Vlaamse lokale en provinciale besturen; het niveau van het Brussels Hoofdstedelijk Gewest. Dit boek verschijnt in de reeks Klachtenmanagement voor openbare besturen. Die reeks wil overheden en organisaties die hun relatie met de burger op een degelijke manier willen uitbouwen, ondersteunen. De inhoud is zowel wetenschappelijk als praktisch van aard. De auteur analyseert en beoordeelt bestaande klachtensystemen. Een aantal praktijkvoorbeelden maken de materie levendig. We gaan op zoek naar de succesfactoren van een goed uitgebouwd klachtenmanagement, rekening houdend met de specificiteit van elke organisatie.
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This book foregrounds the principles of interpretation that scholars employ when reading ancient inscriptions. In order to better come to grips with Canaanite, such as Phoenician, inscriptions, we need to first understand how people wrote and read texts in the ancient Mediterranean world, including that of the Greeks and Romans.
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O livro traz uma análise sobre a fronteira entre ciência e tecnologia, focalizando as novas idéias da era pós-genômica. Com uma linguagem clara e compreensível, o autor analisa os avanços científicos e suas conseqüências para a humanidade, com foco no desenvolvimento da biologia molecular e da genética.
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This book provides a comprehensive overview of non-governmental organizations (NGOs), including their development, structure, marketing, and challenges. It is divided into two sections: "Management Aspects of NGOs in the Area of Development, Marketing and Sourcing", and "Case Studies of NGOs". Chapters discuss the development of NGOs and present case studies of NGOs in various countries, including Ethiopia, Bangladesh, South Africa, and others. They also address such topics as NGOs in the healthcare sector, the effect of the COVID-19 pandemic on the humanitarian supply chain, and how NGOs can protect and preserve cultural heritage.
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RNA. --- Non-coding RNA.
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Regulatory non-protein-coding RNA genes and their transcripts were first found and characterized in bacteria but encompass all biological kingdoms. The complexity of non-coding RNAs (ncRNAs) in terms of number and types increases with degree of biological development, whereby humans and other primates appear to have the largest number. Many regulatory ncRNAs base-pair to a target RNA or DNA and inhibit target function. Bacterial ncRNA genes largely respond to environmental stress conditions and help protect the organism from adverse conditions. The prokaryotic RNAs are for the most part small (<200 bp) and are commonly referred to as small regulatory RNAs (sRNAs). Eukaryotic RNAs consist of small <200 nt RNAs and large>200 nt (termed lncRNAs). The eukaryotic small RNAs include miRNAs, siRNAs, and piRNAs. miRNAs inhibit mRNA functions and may also be associated with cancer. lncRNAs functions are multifaceted and include epigenetic regulation and animal development. The bacterial and archeal immune system CRISPR, and the eukaryotic piwi-interacting RNAs (piRNA) immune system that inhibits mobile elements in germ line cells both function by via RNA transcript/ target DNA heteroduplex base-pairing are a specific class of RNAs that protect cells from invading transposons/and or viruses. siRNAs function in plant and invertebrate immune systems and protect against viral infections.
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RNA. --- Non-coding RNA.
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The discovery of noncoding RNAs (ncRNAs) is changed our understanding of genome, transcriptome, and interactions with proteome in a cell. Since the discovery of the first microRNA (miRNA) called lin-4 on Caenorhabditis elegans in 1993, our understanding of gene expression has deepened. Further miRNA discoveries have led to the investigation of new ncRNA families and their function, biogenesis, and interactions with other types of molecules. Recent developments in bioinformatics, public databases, sequencing technologies, and biochemical techniques have increased our understanding of the biogenesis, function, and interactions of ncRNAs. This book provides an overview of current ncRNA research dealing with human diseases and cancer and plant miRNAs.
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