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This book compiles research on Enterobacterales characterization concerning the presence of genes associated with virulence (adhesins; surface cellulose structures and curli; siderophores, e.g., enterobactin, aerobactin, and yersiniabactin; protectines; invasins or toxins), and, furthermore, bacterial-biofilm-associated phenotypes. Although not directly involved in pathogenicity, the acquisition of multiple antibiotic resistances strongly supports the success of opportunistic Enterobacterales pathogens in invasion, survival, and spread and markedly complicates the treatment of infections. Not only pathogens, but also commensal bacteria, considered harmless and part of the normal microbiota, are exposed to selection pressure and can be a reservoir of mobile genetic elements carrying antibiotic resistance genes. Therefore, the occurrence of drug-resistant bacteria within a commensal population and the possibility to exchange genetic material through horizontal gene transfer may represent a major health concern.

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There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.

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Pichi Sermolli's work with his more than 2750 collections of plants from nearly 150 localities on the Lake Tana expedition in Ethiopia in 1937 was interrupted by World War II, but completed in 1947 at the Royal Botanic Gardens, Kew, and the British Museum (Natural History), UK. It resulted in preliminary accounts of the vegetation published 1938-40 and a taxonomically arranged account in 1951, all in Italian. Pichi Sermolli's observations are difficult to locate due to the imperfect maps of the time, but in this book the authors have reconstructed the sequence of the collections, georeferenced the localities, and updated the identifications of the species. By reconstructing Pichi Sermolli's observations, it is possible to draw conclusions about the vegetation and compare with a recent model of the vegetation of Ethiopia. According to this, the vegetation of the Lake Tana Basin was a complex mosaic of woodland, scrub, forest, farmland and lake shore vegetation now difficult to interpret in detail. Pichi Sermolli's study of the vegetation in the Semien Mountains demonstrated for the first time the zonation of Ericaceous woodland and Afroalpine vegetation, within which he distinguished Carex monostachya bogs, Afroalpine grasslands with Lobelia rhynchopetalum, and stony and rocky Afroalpine vegetation. This book interprets Pichi Sermolli's observations in English and compares them with modern knowledge of the region, partly obtained by the present authors' own field work. It demonstrates how Pichi Sermolli's studies form a valuable contribution to the understanding of the Ethiopian flora and vegetation.

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Long description: Befreit die Rede vom falschen Leben von dem Streben nach einem richtigen? Lehnt man den schnellen Weg des Exitus aus philosophischen und/oder theologischen Gründen und den revolutionären seiner Gräuel und empirischen Erfolglosigkeit in der Geschichte wegen ab, so bleibt ein evolutionärer Weg mit dem existenziellen Imperativ, das Leben - trotz Leid, Schmerz und Tod - so zu gestalten, dass es bejahenswert ist. Das Buch will Spuren und Wege bieten, auf denen der von einem objektiven Sinn befreite, gegen die Absurdität revoltierende und die Polarität des Lebens integrierende Mensch seinem geliehenen Leben Richtiges (Glück und Sinn v. a. in einzelnen Situationen) abgewinnen kann. Über die Hinwendung - in Achtsamkeit und Sorge - auf das Ich, ein Du und ein Etwas lässt eine glück- und sinnorientierte Lebenskunst Momente des Glücks und subjektiven Sinn - auf den Ebenen der körperlichen Sinne, der Gefühle, der inneren Bilder und vielleicht auch der Transzendenz - entwickeln.

Life sciences.